Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer's type dementia.

Objectives: To study the interplay between serum concentrations of homocysteine, steroid hormones and vitamins B and mutations in 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, in association to Alzheimer's type dementia (ATD).

Design And Methods: Case-control study including 19 individuals diagnosed with ATD and 36 healthy controls. Serum concentrations of the analytes were determined and MTHFR 1298A-->C mutation was screened by PCR-RFLP.