Publications by authors named "Sara Ruiz-Garcia"
Article Synopsis
- The JAK/STAT pathway is often disrupted in T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic lymphoma (LBL), but there are no approved specific therapies targeting this issue.
- The study found that hypermethylation of the SOCS3 gene is a common occurrence in T-ALL/LBL, suggesting it could be a potential target for treatment.
- SOCS3 plays a critical role in regulating the JAK/STAT pathway and its impairment allows for its constant activation, making SOCS3 a promising therapeutic target for these diseases.
In the quest for more effective radiation treatment options that can improve both cell killing and healthy tissue recovery, combined radiation therapies are lately in the spotlight. The molecular response to a combined radiation regime where exposure to an initial low dose (priming dose) of ionizing radiation is administered prior to a subsequent higher radiation dose (challenging dose) after a given latency period have not been thoroughly explored. In this study we report on the differential response to either a combined radiation regime or a single challenging dose both in mouse in vivo and in human ex vivo thymocytes.
View Article and Find Full Text PDF