Publications by authors named "Sara Rojas-Vazquez"
Article Synopsis
- Senescent cells accumulate with age, leading to tissue dysfunction and diseases, making their detection challenging in aging research.
- The study introduces a new fluorogenic probe (sulfonic-Cy7Gal) that helps detect cellular senescence by releasing a measurable fluorophore after being cleaved by β-galactosidase in mice.
- The probe's effectiveness is shown to correlate with age-related anxiety and the temporary effects of senolytic treatment, suggesting it could be used for ongoing monitoring of enzymatic activities related to aging.
The adult mammalian brain contains distinct neurogenic niches harboring populations of neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of neurons during the lifetime. However, their ability to produce new progeny declines with age. The microenvironment of these specialized niches provides multiple cellular and molecular signals that condition NSC behavior and potential.
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