Publications by authors named "Sara Rahbar"
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with rising incidence and with 5-years overall survival of less than 8%. PDAC creates an immune-suppressive tumor microenvironment to escape immune-mediated eradication. Regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSC) are critical components of the immune-suppressive tumor microenvironment.
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- A computational model was developed to analyze the epidermal growth factor receptor (EGFR) signaling pathway, which is crucial for understanding cancer dynamics and predicting quantitative responses.
- The study specifically examined the interaction of Arsenic trioxide (ATO) with the EGFR signaling pathway, highlighting its role as a chemotherapy agent that affects EGFR expression based on concentration.
- By integrating Fuzzy Logic and Petri Nets, the model improved insights into the dynamics of the EGFR signaling pathway, enhancing the ability to analyze biological networks more comprehensively.
Article Synopsis
- - The study explores how protein activities influence transition probabilities in the budding yeast cell cycle network, aiming to identify stable protein interactions within a Boolean network model.
- - A Markov chain model was developed, extending the existing Boolean network to include apoptosis, and genetic algorithms were employed to optimize kinetic parameters for better transition probabilities during the cell cycle phases.
- - Results showed that optimizing these parameters increased the robustness of the cell cycle by raising the stability of the stationary G1 phase and reducing the number of attractors in the model, emphasizing the impact of protein interactions on network dynamics.
Cryopreservation is a useful approach to preserve male fertility for assisted reproduction technique and other evaluations. In spite of extensive development in the cryopreservation field, there are biological and biochemical points including DNA fragmentation and antioxidant which should be illuminated to preserve fertility in safe form. Several molecular markers such as coding and noncoding RNAs are transferred from spermatozoa into oocyte via fertilization.
View Article and Find Full Text PDFmiRNAs (MicroRNAs), known as noncoding and important endogenous factors regulating the expression protein-coding genes, are vital regulators in each biological process. Thus, this study aims to explore the key role of four microRNAs in regulating the spermatogenesis. To conduct this experiment, 55 infertile and fertile men provided the study with the sperm and testicular tissue samples.
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