Publications by authors named "Sara Pryce"
Article Synopsis
- Research over the past 20 years has focused on how estrogenic chemicals affect amphibians, but the specific molecular interactions in developing amphibians remain largely unexplored.
- In a study using Xenopus laevis and exposure to 17α-ethynylestradiol (EE2) at different concentrations, the researchers observed no significant effects on gene expression at 31 days post-hatch, but notable changes occurred by 89 days post-hatch, impacting genes related to steroid signaling, cholesterol synthesis, and vitellogenesis.
- The findings suggest that specific gene sets from fish studies can be applied to juvenile amphibians but may not be applicable to sexually undifferentiated ones, highlighting the potential for these genes to predict adverse effects in
Effects of 17α-ethynylestradiol on sexual differentiation and development of the African clawed frog (Xenopus laevis).
Comp Biochem Physiol C Toxicol Pharmacol
November 2012
Several studies have shown that exposure of amphibians, including the African clawed frog (Xenopus laevis), to potent estrogens at critical times during development results in feminization and/or demasculinization. However, genotyping of X. laevis has only recently become possible, so studies performed in the past were rarely able to make explicit linkages between genetic and phenotypic sex.
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