Publications by authors named "Sara Protzek"
Patients with metastatic pancreatic ductal adenocarcinoma survive longer if disease spreads to the lung but not the liver. Here we generated overlapping, multi-omic datasets to identify molecular and cellular features that distinguish patients whose disease develops liver metastasis (liver cohort) from those whose disease develops lung metastasis without liver metastases (lung cohort). Lung cohort patients survived longer than liver cohort patients, despite sharing the same tumor subtype.
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- The study focuses on pancreatic ductal adenocarcinomas (PDAC) and highlights the need for early detection, suggesting biomarkers like GDF15 and LCN2 could be valuable in this context.
- Analysis of circulating levels of GDF15 and LCN2 in PDAC patients showed higher concentrations compared to healthy controls and those with benign diseases, with GDF15 linked to disease progression and mortality.
- Findings indicate that GDF15 is a promising biomarker for early detection and prognosis of PDAC, while LCN2 could enhance diagnostic accuracy when combined with GDF15 or CA19-9.
Targeted Transcriptional Analysis of IgA Vasculitis, IgA Nephropathy, and IgA-Dominant Infection-Related Glomerulonephritis Reveals Both Distinct and Overlapping Immune Signatures.
Kidney360
June 2023
Key Points: Skin IL-9, calprotectin, and KIR gene expression may be predictive of subsequent kidney involvement in patients with IgAV. Histologically similar patients with IgAN, IgAV, and IgA-IRGN can be distinguished by their immune transcriptomes. Kidney biopsies from patients with IgA-IRGN are enriched for transcripts involved in granulocyte chemotaxis.
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