Polysaccharide-coated liposomal formulations for dental targeting.

The efficacy of treatments of oral ailments is often challenged by a low residence time of the conventional pharmaceutical formulations in the oral cavity, which could be improved by using bioadhesive formulations. This in vitro study investigated charged liposomes, both uncoated and coated through electrostatic deposition with polysaccharides (chitosan, alginate and pectin), as bioadhesive systems for the oral cavity. First, formulations that provided liposomes fully coated with polysaccharide were selected.

Formulation of polysaccharide-based nanoparticles for local administration into the oral cavity.

The efficacy of treatments for oral ailments is often challenged by a low residence time of the conventional pharmaceutical formulations in the oral cavity. The residence time in the oral cavity could be improved by using bioadhesive formulations, such as preparations based on polysaccharides. This study describes the formulation and the evaluation of polysaccharide-based nanosystems as drug delivery systems addressed to the oral cavity.

Multivariate analysis for the optimization of polysaccharide-based nanoparticles prepared by self-assembly.

Polysaccharide-based nanoparticles are promising carriers for drug delivery applications. The particle size influences the biodistribution of the nanoparticles; hence size distributions and polydispersity index (PDI) are critical characteristics. However, the preparation of stable particles with a low PDI is a challenging task and is usually based on empirical trials.

Formulation and preparation of stable cross-linked alginate-zinc nanoparticles in the presence of a monovalent salt.

Polysaccharide-based nanoparticles can be formed, under the right conditions, when a counterion is added to a dilute polysaccharide solution. In this study, the possibility of preparing stable alginate nanoparticles cross-linked with zinc was investigated. The effects of the ionic strength of the solvent and the concentration of zinc were studied.