Erratum: Combining patient-lesion and big data approaches to reveal hippocampal contributions to spatial memory and navigation.

[This corrects the article DOI: 10.1016/j.isci.

Combining patient-lesion and big data approaches to reveal hippocampal contributions to spatial memory and navigation.

Classic findings of impaired allocentric spatial learning and memory following hippocampal lesions indicate that the hippocampus supports cognitive maps of one's environment. Many studies assess navigation in vista space virtual reality environments and compare hippocampal-lesioned individuals' performance to that of small control samples, potentially stifling detection of preserved and impaired performance. Using the mobile app we examined navigation in diverse complex environments in two individuals with hippocampal lesions relative to demographically matched controls ( = 17,734).

Ask how they did it: untangling the relationships between task-specific strategy use, everyday strategy use, and associative memory.

Objective: Past research has shown that self-reported everyday strategy use and task-specific strategy use are related to associative memory performance in aging. Understudied is the relationship between these types of strategy use, whether they predict associative memory performance, and how this may differ across genders.

Method: A sample of older adults ( = 566, 53% female, ages 60-80) completed this online study.

Emotion regulation relates to clinical characteristics and quality of life but not daily functioning in psychosis spectrum outpatients.

Difficulties in emotion regulation (ER) can negatively impact the clinical course and outcomes of a range of psychiatric conditions, including psychosis spectrum disorders. Individuals with psychosis may exhibit poorer ER abilities, which have been associated with increased severity and distress of psychotic symptoms. A paucity of research has investigated the clinical correlates of ER in psychosis and the influence of these difficulties on indices of recovery, such as daily functioning and quality of life.

An ecologically sensitive measure of executive cognition (the Breakfast Task) improves prediction of functional outcome in schizophrenia.

Previous work has found that the Breakfast Task (BT), a computerized, ecologically informed executive ability measure, is sensitive to group differences in aging, acquired brain injury, and Parkinson's disease. We investigated whether this measure improves the prediction of functional status over and above standard measures of general intellectual ability, relationship perception, life skills, and symptom severity in individuals with schizophrenia. Regression analyses were conducted to evaluate the joint and incremental validity of the BT in predicting functional disability scores on the World Health Organization Disability Assessment Scale (WHODAS 2.

Reminders activate the prefrontal-medial temporal cortex and attenuate forgetting of event memory.

Replicas of an aspect of an experienced event can serve as effective reminders, yet little is known about the neural basis of such reminding effects. Here we examined the neural activity underlying the memory-enhancing effect of reminders 1 week after encoding of naturalistic film clip events. We used fMRI to determine differences in network activity associated with recently reactivated memories relative to comparably aged, non-reactivated memories.

Changes in patterns of neural activity underlie a time-dependent transformation of memory in rats and humans.

The dynamic process of memory consolidation involves a reorganization of brain regions that support a memory trace over time, but exactly how the network reorganizes as the memory changes remains unclear. We present novel converging evidence from studies of animals (rats) and humans for the time-dependent reorganization and transformation of different types of memory as measured both by behavior and brain activation. We find that context-specific memories in rats, and naturalistic episodic memories in humans, lose precision over time and activity in the hippocampus decreases.

Selective scene perception deficits in a case of topographical disorientation.

Topographical disorientation (TD) is a neuropsychological condition characterized by an inability to find one's way, even in familiar environments. One common contributing cause of TD is landmark agnosia, a visual recognition impairment specific to scenes and landmarks. Although many cases of TD with landmark agnosia have been documented, little is known about the perceptual mechanisms which lead to selective deficits in recognizing scenes.

Recovering and preventing loss of detailed memory: differential rates of forgetting for detail types in episodic memory.

Episodic memories undergo qualitative changes with time, but little is known about how different aspects of memory are affected. Different types of information in a memory, such as perceptual detail, and central themes, may be lost at different rates. In patients with medial temporal lobe damage, memory for perceptual details is severely impaired, while memory for central details is relatively spared.