Pandemic response across Ohio's public universities: Novel approaches, emergent challenges and future opportunities.

We describe and analyze case investigation and contact tracing (CICT) efforts across Ohio's public universities in response to COVID-19 to distill challenges and lessons learned and suggest future opportunities for universities to mobilize in the face of emergent public health crises. Faculty, staff, and graduate students from Ohio's fourteen public universities. In-depth, semi-structured interviews were conducted with representatives from nine of the 14 universities; representatives from the remaining five universities completed a brief questionnaire.

Cholinesterase inhibitors and stress: effects on brain muscarinic receptor density in mice.

Exposure to the reversible cholinesterase inhibitor, pyridostigmine bromide (PB), in conjunction with stress, has been suggested as a possible cause of Gulf War Syndrome. This work explores the hypothesis that PB exposure coupled with stress will alter cholinergic receptor density based on the rationale that prolonged exposure to PB and stress will lead to increased stimulation of cholinergic receptors due to the reduced capacity to degrade acetylcholine, leading to changes in receptor levels. Male C57Bl6 mice were exposed to PB (3 or 10 mg/kg/day) or physostigmine (2.

Establishment of a low birth weight registry and initial outcomes.

The study was conducted to evaluate a regional, prospective database of information on mothers of low birth weight (LBW) infants. The database informs on unidentified or under-reported modifiable risk factors from which evidence-based, targeted community intervention strategies could be designed to lower the rate of low birth weight in the region. The LBW Registry is based on informed consent, a semi-structured face-to-face (FTF) interview with the mother of the newborn LBW infant, medical record review, and birth certificate worksheet data collection.

Diurnal behavioral and endocrine effects of chronic shaker stress in mice.

Experiments were performed in C57BL/6J male mice to determine 1) light/dark effects of acute and chronic shaker stress on open field behavioral patterns and 2) light/dark effects of chronic stress on plasma corticosterone and oxytocin. Shaker stress was applied acutely (15 min) or chronically (3 or 7 days). Mice were tested in the open field in the light or dark phase of the circadian cycle.

Behavioral changes after acetylcholinesterase inhibition with physostigmine in mice.

The effect of the central and peripheral acetylcholinesterase (AChE) inhibitor, physostigmine (PHY), was examined on spatial memory using a water maze, motor activity as well as acoustic startle response (ASR) and prepulse inhibition (PPI) in C57BL/6J mice. PHY was administered intraperitoneally (IP) at doses of 0.0, 0.