Honeycomb worm bioconstructions persist under combined human and wave-related disturbances.

Marine bioconstructions and their ecological functions are increasingly threatened by compounded natural disturbances and direct and indirect impacts of anthropogenic activities. Through a manipulative experiment in the field, we assessed the response of intertidal biogenic patches built by the honeycomb worm, Sabellaria alveolata, to combined disturbances. Repeated battering events, simulating those associated with waves, were applied on intact or previously damaged bioconstructions, mimicking those impacted by harvesting of infaunal organisms.

Self-supervised learning for characterising histomorphological diversity and spatial RNA expression prediction across 23 human tissue types.

As vast histological archives are digitised, there is a pressing need to be able to associate specific tissue substructures and incident pathology to disease outcomes without arduous annotation. Here, we learn self-supervised representations using a Vision Transformer, trained on 1.7 M histology images across 23 healthy tissues in 838 donors from the Genotype Tissue Expression consortium (GTEx).