Publications by authors named "Sara Nolin"
Article Synopsis
- Older adults often take medications with anticholinergic (ACH) activity, which can negatively impact cognitive function, particularly as they age.
- A study involving over 20,000 adults found a strong link between higher ACH burden and accelerated cognitive decline in those aged 45 and older.
- Increased physical activity was associated with less cognitive decline, especially in older adults, suggesting it may help counteract the negative effects of ACH medications.
Objective: To evaluate the construct validity of the NIH Toolbox Cognitive Battery (NIH TB-CB) in the healthy oldest-old (85+ years old).
Method: Our sample from the McKnight Brain Aging Registry consists of 179 individuals, 85 to 99 years of age, screened for memory, neurological, and psychiatric disorders. Using previous research methods on a sample of 85 + y/o adults, we conducted confirmatory factor analyses on models of NIH TB-CB and same domain standard neuropsychological measures.
25 years of neurocognitive aging theories: What have we learned?
Front Aging Neurosci
September 2022
The past 25 years have provided a rich discovery of at least four fundamental patterns that represent structural and functional brain aging across multiple cognitive domains. Of the many potential patterns of brain aging, few are ever examined simultaneously in a given study, leading one to question their mutual exclusivity. Moreover, more studies are emerging that note failures to replicate some brain aging patterns, thereby questioning the universality and prevalence of these patterns.
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