Publications by authors named "Sara Nobile"
Article Synopsis
- This study explores the significance of pathological staging in predicting outcomes for pancreatic cancer patients after surgery and neoadjuvant therapy.
- It involves 389 patients from two Italian centers and demonstrates that a modified staging system performs better in predicting survival compared to standard methods.
- The findings suggest that certain patients, particularly those with specific tumor characteristics, may benefit from adjuvant therapy, despite no overall survival difference observed in the entire cohort.
Background: Data on recurrence after post-neoadjuvant pancreatectomy are scant. This study investigated the incidence and pattern of recurrence in patients with initially resectable and borderline resectable pancreatic ductal adenocarcinoma who received post-neoadjuvant pancreatectomy. Furthermore, preoperative predictors of recurrence-free survival (RFS) and their interactions were determined.
View Article and Find Full Text PDFBackground: Implementing a prospective lymphadenectomy protocol, we investigated the nodal yields and metastases per anatomical stations and nodal echelon following upfront pancreatoduodenectomy (PD) for cancer. Next, the relationship between the extension of nodal dissection, the number of examined and positive nodes (ELN/PLN), disease staging and prognosis was assessed.
Methods: Lymphadenectomy included stations 5, 6, 8a-p, 12a-b-p, 13, 14a-b, 17, and jejunal mesentery nodes.
Introduction: With the prolongation of life expectancy, an increasing number of elderly patients are evaluated for pancreatic surgery. However, the influence of increasing age on outcomes after pancreaticoduodenectomy (PD) is still unclear, especially in octogenarians. Aim of this study is to evaluate the perioperative characteristics and outcomes of octogenarians undergoing PD.
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- A study was conducted to assess the impact of the COVID-19 pandemic on pancreatic surgery, comparing data from the first half of 2020 to the same period in 2019 across ten Italian referral centers.
- Surgical volumes dropped by 18.7% in 2020, with significant reductions in treating benign diseases and neuroendocrine tumors, while many clinical processes remained similar to previous years.
- Despite decreased surgical activity, patient care levels in key centers were maintained, though future diagnoses may reflect more advanced disease stages due to fewer surgeries during the pandemic.
Background: The pattern of nodal spread in body-tail pancreatic ductal adenocarcinoma (PDAC) has been poorly investigated. This study analyzed the characteristics of lymph node (LN) involvement and the prognostic role of nodal metastases stratified by LN stations.
Methods: All upfront distal pancreatectomies (DPs) for PDAC (2000-2017) with complete information on station 8,10,11, and 18 were included.
Pancreatic surgery is being offered to an increasing number of patients every year. Although postoperative outcomes have significantly improved in the last decades, even in high-volume centers patients still experience significant postoperative morbidity and full recovery after surgery takes longer than we think. In recent years, enhanced recovery pathways incorporating a large number of evidence-based perioperative interventions have proved to be beneficial in terms of improved postoperative outcomes, and accelerated patient recovery in the context of gastrointestinal, genitourinary and orthopedic surgery.
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