Publications by authors named "Sara Naya-Forcano"
Cell Death Dis
October 2024
Article Synopsis
- - Niemann-Pick disease Type C (NPC) is linked to mutations in the NPC1 protein that disrupt cholesterol transport, leading to lipid buildup and psychiatric problems.
- - In an NPC mouse model, researchers discovered that mGluR (metabotropic glutamate receptors) accumulate abnormally inside cells, affecting their function and leading to changes in long-term depression (a form of synaptic plasticity).
- - Treatment with the mGluR antagonist CTEP lowered mGluR-related issues and improved psychiatric symptoms, suggesting alterations in mGluR play a role in NPC and offering potential new therapies for affected individuals.
