Publications by authors named "Sara Natali"
Article Synopsis
- Type-2 immune responses are major contributors to chronic inflammatory diseases like asthma, impacting public health.
- PPARγ is a transcription factor that drives the development of specific immune cells (M2-macrophages and alveolar macrophages) and plays a crucial role in T cells and dendritic cells (DCs) in type-2 immune responses.
- Research shows that PPARγ is essential for Th2 effector functions during allergic reactions, particularly in how it interacts with IL-4 and IL-33 to enhance immune responses, highlighting its previously unrecognized proinflammatory role.
Background: Patients with pollen allergies are frequently polysensitized. Pollens contain epitopes that are conserved across multiple species.
Objective: We sought to demonstrate that cross-reactive T cells that recognize conserved epitopes show higher levels of expansion than T cells recognizing monospecific epitopes because of more frequent stimulation.