The Pathological Evaluation of Autophagy-Related Protein (LC3B) and Its Association with the Infiltration of Immune Cells in Glioma.

Background: Tumor cell autophagy can influence cellular immunity by participation in the recognition and modification of tumor-related antigens.

Objectives: The objective of this study was to evaluate the immunohistochemical expression of the autophagy-related marker; light chain 3B (LC3B) in tumor cells and the assessment of T lymphocytes by a cluster of differentiation 3 (CD3) in gliomas, and to correlate them with the available clinic-pathological variables in glioma patients.

Materials And Methods: Immunohistochemical staining for LC3B and CD3 was performed on 60 paraffin-embedded glioma tissue.