Publications by authors named "Sara Metaoy"
Adjuvant local antibiotic therapy in the management of diabetic foot osteomyelitis.
Clin Diabetes Endocrinol
December 2024
Background: The management of diabetic foot osteomyelitis (DFO) is complex. The targeted use of adjuvant local antibiotics, in the form of biocomposite bone void filler, in DFO, can enhance patient outcomes while minimising the adverse effects associated with systemic antibiotic therapy and its shortcomings.
Methods: We reviewed a series of 105 consecutive patients who underwent surgical management for diabetic foot osteomyelitis.
Microbial profile of diabetic foot osteomyelitis from the northwest of England.
Clin Diabetes Endocrinol
November 2024
Article Synopsis
- Osteomyelitis in diabetic foot patients is complicated by polymicrobial infections, which have high rates of persistence and recurrence, prompting this study to evaluate microbiological profiles and resistance patterns.
- A retrospective review of 105 patients showed that only 42% achieved infection eradication, while 18% experienced persistence and 40% faced late recurrence, with 72% of cases exhibiting polymicrobial growth, primarily from gram-positive bacteria.
- Notably, Staphylococcus aureus was the most prevalent pathogen, and both gram-positive and gram-negative bacteria demonstrated significant antibiotic resistance, highlighting challenges in treatment strategies for persistent infections.
Article Synopsis
- Membranoproliferative glomerulonephritis (MPGN) is a kidney condition identified through biopsy, with various causes, and this study explores data from a UK renal center over 20 years.* -
- The study involved 38 identified patients, primarily older (median age 61), with a significant percentage suffering from immune complex-mediated MPGN, and highlighted treatment approaches and clinical outcomes.* -
- Findings indicated that nearly 50% of patients progressed to end-stage kidney disease (ESKD) or died, suggesting the need for personalized patient management and further research to improve understanding and outcomes.*