Publications by authors named "Sara May"

Article Synopsis
  • The study investigates the gene expression profiles of circulating CD14+ monocytes in patients with rheumatoid arthritis and interstitial lung disease (RA-ILD) to better understand the disease's pathogenesis.
  • Researchers collected blood samples from various groups, including RA patients with and without lung disease, and those with idiopathic pulmonary fibrosis (IPF) and healthy controls, analyzing the RNA for gene expression differences.
  • Findings revealed that monocytes in RA-ILD patients exhibited unique gene expression patterns, particularly in inflammation and fibrosis regulation, linking their immune features more closely to IPF than to RA without lung involvement, which could inform future therapeutic strategies.
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Article Synopsis
  • The study aimed to investigate how inducible laryngeal obstruction (ILO) symptoms vary among adults of different ages, using a sample of 67 patients over 16 years old confirmed to have ILO.
  • Results showed that adults under 50 reported significantly more symptoms like shortness of breath and chest tightness compared to those 50 and older.
  • The findings suggest that older adults might have less obvious ILO symptoms and anxiety, indicating a need for increased awareness and evaluation in this age group.
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Background: The accuracy of documentation of body weight and fluid balance in hospitalized patients is frequently questioned.

Methods: We conducted a survey to understand provider perceptions of the accuracy of intake, output, and weight charting in the electronic medical record. We sent a six-item questionnaire to nurses and physicians who provide inpatient service in a community-based teaching hospital of the Northeastern United States.

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Article Synopsis
  • Cefazolin is the preferred antibiotic for preventing surgical site infections (SSIs), but prescribing can be affected by patient-reported penicillin allergies.
  • In April 2022, Nebraska Medicine adjusted electronic medical record alerts to reduce unnecessary restrictions on prescribing cefazolin for patients with non-severe penicillin allergies.
  • A study found that following this change, the use of cefazolin in patients with documented penicillin allergies rose significantly, with no increase in adverse reactions or complications.
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Vocal cord dysfunction (VCD) is often under-recognized and/or misdiagnosed as asthma. Although post-viral syndrome has been suggested as a contributing factor in VCD, there is limited data on infection-associated VCD. The purpose of this study was to assess and describe the proportion of patients who were diagnosed with VCD who did and did not report infection preceding VCD diagnosis.

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Objectives: Interstitial lung disease (ILD) is associated with significant mortality in rheumatoid arthritis (RA) patients with key cellular players remaining largely unknown. This study aimed to characterize inflammatory and myeloid derived suppressor cell (MDSC) subpopulations in RA-ILD as compared to RA, idiopathic pulmonary fibrosis (IPF) without autoimmunity, and controls.

Methods: Peripheral blood was collected from patients with RA, RA-ILD, IPF, and controls (N = 60, 15/cohort).

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Background: The Antimicrobial Stewardship Program (ASP) at Nebraska Medicine collaborated with a board-certified allergist to develop a penicillin allergy guidance document for treating inpatients with self-reported allergy. This guidance contains an algorithm for evaluating and safely challenging penicillin-allergic patients with beta-lactams without inpatient allergy consults being available.

Methods: Following multi-disciplinary review, an order set for beta-lactam graded challenges (GC) was implemented in 2018.

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Purpose: The purpose of this study is to characterize mothers' experiences within a mother/infant dyad postpartum primary care program (Dyad) following gestational diabetes mellitus (GDM) to inform improvements in the delivery of care.

Methods: A qualitative pilot study of women (n = 10) enrolled in a mother/infant Dyad program was conducted in a primary care practice at a large, urban academic medical center. Respondents were asked a series of open-ended questions about their experience with GDM, the Dyad program, and health behaviors.

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Background: Gestational diabetes mellitus (GDM), a common complication of pregnancy, is associated with a 10-fold increased risk of type 2 diabetes mellitus (T2DM) compared to the general population. Evidence-based guidelines recommend that patients with GDM receive postpartum care for T2DM risk reduction including an oral glucose tolerance test (OGTT) 4-12 weeks after delivery, yet half of patients with GDM did not return for their postpartum visits by 12 weeks postpartum. Additionally, only 10% utilize primary care within 12 months of delivery and one-third of GDM patients receive timely postpartum OGTT.

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Scientific communication is facilitated by a data-driven, scientifically sound taxonomy that considers the end-user's needs and established successful practice. In 2013, the community voiced near unanimous support for a concept of that represented a clade comprising all agriculturally and clinically important species, including the species complex (FSSC). Subsequently, this concept was challenged in 2015 by one research group who proposed dividing the genus into seven genera, including the FSSC described as members of the genus , with subsequent justification in 2018 based on claims that the 2013 concept of is polyphyletic.

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Aims: Type 2 diabetes mellitus (T2DM) rates continue to increase across women of reproductive age in the United States. The Ohio Type 2 Diabetes Learning Collaborative aimed to improve education and screening for T2DM among women aged 18-44years at high risk for developing T2DM.

Methods: Fifteen primary care practices across Ohio participated in a 12-month quality improvement (QI) collaborative, which included monthly calls to share best practices, one-on-one QI coaching, and Plan-Do-Study-Act cycles.

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Background: Group B Streptococcus (GBS) is the leading infectious cause of neonatal morbidity and mortality in the United States. Intrapartum administration of antibiotics to mothers with positivity to GBS is performed for prevention, with penicillin being the drug of choice. Previous studies have noted an increase in atopic diseases other than drug allergy associated with intrapartum antibiotic exposure.

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Background: Secondhand smoke (SHS) exposure can trigger asthma exacerbations in children. Different studies have linked increased asthma symptoms, health care use, and deaths in children exposed to SHS, but the risk has not been quantified uniformly across studies.

Objective: To perform a systematic review and meta-analysis to evaluate and quantify asthma severity and health care use from SHS exposure in children.

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Background: Secondhand smoke (SHS) exposure is known to trigger asthma, but asthma disease severity and comorbidities in children exposed to SHS are not very well quantified.

Objective: To identify comorbidities and understand health care usage in children with asthma exposed to SHS (cases) compared with children with asthma but without SHS exposure (controls).

Methods: A retrospective nested matched case-and-control study was conducted with children 5 to 18 years old who were enrolled in the Pediatric Asthma Management Program.

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Background: Internal medicine residents receive limited training on how to be good stewards of health care dollars while preserving high-quality care.

Intervention: We implemented a clinical process change and an educational intervention focused on the appropriate use of preoperative diagnostic testing by residents at a Veterans Administration (VA) medical center.

Methods: The clinical process change consisted of reducing routine ordering of preoperative tests in the absence of specific indications.

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Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating respiratory condition that leads to significant burden, both medically and financially. It affects millions of people worldwide and causes significant morbidity and mortality. Most detailed information related to its prevalence, morbidity, and mortality comes from high-income countries, but 90% of COPD-related deaths occur in low- and middle-income countries.

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Objective: This study aimed to evaluate the effectiveness of massage with or without guided imagery in reducing anxiety prior to cardiac catheterization.

Method: A total of 55 inpatients and outpatients received massage, guided imagery, or massage with guided imagery prior to cardiac catheterization. Self-reported anxiety levels and blood pressure (BP) and heart rate (HR) were evaluated in participants and a matched comparison group.

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With increases in large animal-feeding operations to meet consumer demand, adverse upper and lower respiratory health effects in exposed agriculture workers are a concern. The aim of this study was to review large animal confinement feeding operational exposures associated with respiratory disease with a focus on recent advances in the knowledge of causative factors and cellular and immunological mechanisms. A PubMed search was conducted with the keywords airway, farm, swine, dairy, horse, cattle inflammation, organic dust, endotoxin, and peptidoglycan, among items were published between 1980 and now.

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