Publications by authors named "Sara M Gonzalez-Rodulfo"
Article Synopsis
- Cholesterol plays a crucial role in maintaining neuronal membrane integrity and proper function, and imbalances can lead to neurodegenerative diseases and age-related changes.
- This study investigates cholesterol levels in the inner ear of young and aged mice, finding that levels decrease with age, linked to increased expression of the cholesterol enzyme CYP46A1.
- Pharmacological activation of CYP46A1 with efavirenz reduces cholesterol in outer hair cells, negatively impacting hearing, but dietary phytosterol supplementation can help counteract this effect, suggesting a potential strategy for preventing hearing loss.
