Publications by authors named "Sara Laurencin-Dalacieux"
Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification.
Biochim Biophys Acta Mol Cell Biol Lipids
August 2020
Article Synopsis
- - Lysophosphatidic acid (LPA) is a vital lipid that impacts bone growth and remodeling, with global Lpar1-knockout mice showing significant bone growth defects.
- - The study specifically investigates osteoblasts by creating osteoblast-specific Lpar1 knockout mice (Lpar1-∆Ob), which revealed issues like reduced bone mineralization and increased porosity, but no severe bone defects.
- - Findings indicate that LPA plays a critical role in bone mass regulation, influencing osteocyte function and mineralization processes, which are crucial for maintaining bone health.