Engaging Pharmacists to Crowdsource a Fine-grained Medication Risk Scale: An Initial Measurement Study Using Paired Comparisons of Medications.

A coarse classification of medications into two risk categories, one for high-risk medications and one for all others, allows people to focus safety improvement work on medications that carry the highest risks of harm. However, such coarse categorization does not distinguish the relative risk of harm for the majority of medications. To begin to develop a more fine-grained measurement scale for the relative risk of harm spanning many medications, we performed an experiment with 18 practicing pharmacists.

Novel FR-900493 Analogues That Inhibit the Outgrowth of Spores.

The spectrum of antibacterial activity for the nucleoside antibiotic FR-900493 () can be extended by chemical modifications. We have generated a small focused library based on the structure of and identified UT-17415 (), UT-17455 (), UT-17460 (), and UT-17465 (), which exhibit anti- growth inhibitory activity. These analogues also inhibit the outgrowth of spores at 2× minimum inhibitory concentration.