Publications by authors named "Sara Kolehmainen"
Background: A few prospective cohort studies support the safety of switching from intravenous to subcutaneous administration of vedolizumab during maintenance therapy in patients with inflammatory bowel disease. Real-life data on switching after intravenous induction therapy are lacking.
Objective: The aim was to obtain real-world data on subcutaneous vedolizumab treatment in patients with inflammatory bowel disease after switching from intravenous vedolizumab induction or maintenance therapy, and to evaluate treatment persistence, safety, and changes in disease activity and serum vedolizumab concentrations.
Article Synopsis
- Researchers investigated dual biological therapy (DBT) as a new treatment for patients with refractory inflammatory bowel disease (IBD), focusing on its efficacy and safety.
- The study included 16 patients, mainly with Crohn's disease, who underwent 22 trials of DBT using combinations like adalimumab and ustekinumab, with a median follow-up of nine months.
- Results showed that 32% of patients achieved remission, some experienced reduced corticosteroid reliance, and notable safety concerns included a 19% infection rate, indicating the need for further long-term studies on DBT.
Objectives: We set out to determine the reasons for serum vedolizumab (VDZ) trough concentration (TC) measurements in inflammatory bowel disease (IBD) patients and to evaluate treatment modifications after therapeutic drug measurement (TDM). We also evaluated the effect of increased dosing on patients' response to VDZ therapy.
Methods: We performed a retrospective cohort study of IBD patients who received VDZ therapy at Helsinki University Hospital and whose VDZ levels were measured between June 2014 and December 2018.
The aim of this study is to assess the impact of biological therapy on the colectomy rate and indications for colectomy in ulcerative colitis (UC) at Helsinki University Hospital (HUH) catchment area in Finland. This study was conducted retrospectively by comparing two cohorts of UC and indeterminate colitis patients that underwent colectomy in a single centre in HUH during the years 2005-2007 and 2014-2016. All patient data were collected from hospital patient records.
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