Publications by authors named "Sara Kimiko Suzuki"
Cells typically exist in a highly dynamic environment, which cannot easily be recreated in culture dishes or microwell plates. Microfluidic devices can provide precise control of the time, dose, and orientation of a stimulus, while simultaneously capturing quantitative single-cell data. The approach is particularly powerful when combined with the genetically tractable yeast model organism.
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- The yeast mating pathway is a complex system involving pheromone receptors, G proteins, and proteins that help with cell growth and gene expression.
- The study found that the G-protein α subunit Gpa1 signals through proteins like Dia2 and Vps34, which are important for vacuolar sorting and autophagy.
- Researchers demonstrated that pheromone exposure triggers vacuolar targeting of a cytoplasmic protein, requiring Dia2 and indicating a new aspect of the mating signaling pathway that could affect protein recycling for mating preparation.