Sesquiterpene Lactones with the 12,8-Guaianolide Skeleton from Algerian .

In continuing our investigation on the chemical diversity of Algerian plants, we examined , whose chemical composition has been poorly studied. The present work was aimed at characterizing the secondary metabolite pattern of the CHCl extract of the aerial parts of this plant that displayed antiproliferative properties in a preliminary screening on HeLa cell line. The chemical analysis led us to characterize the bioactive oxygenated terpenoid fraction which includes, within major known metabolites, two new minor sesquiterpene lactones, centaurolide-A () and centaurolide-B ().