Publications by authors named "Sara I Shoushtari"
Article Synopsis
- T helper 1 (Th1)-mediated immune rejection is the main reason for graft failure after transplantation, influenced by interactions between different types of dendritic cells, particularly CD11b+ DC2 and CD103+ DC1.
- In non-inflamed corneal beds, migratory CD103+ DC1 cells maintain a tolerogenic function that helps suppress harmful immune responses and promote graft survival through mechanisms like IL-10 and the PD-L1/PD-1 pathway.
- In contrast, in inflamed corneal beds, Th1 cells switch CD103+ DC1 cells to an immunostimulatory state, leading to graft failure; however, transferring tolerogenic CD103+ DC1s can inhibit this negative
Prevalence and Determinants of Unmet Social Needs Among Rural and Urban Veterans.
J Health Care Poor Underserved
July 2023
Purpose: To examine the prevalence and determinants of nine unmet social needs among rural compared with urban Veterans.
Methods: Retrospective study using survey data collected in 2020 merged with Veterans Health Administration (VA) administrative data. For each unmet need, separate logistic regression modes were run predicting the odds of rural compared with urban Veterans endorsing the need adjusting for sociodemographic characteristics and comorbidities.
Protein synthesis is an essential process that affects major cellular functions including growth, energy production, cell signaling, and enzymatic reactions. However, how it is impacted by aging and how the translation of specific proteins is changed during the aging process remain understudied. Although yeast is a widely used model for studying eukaryotic aging, analysis of age-related translational changes using ribosome profiling in this organism has been challenging due to the need for isolating large quantities of old cells.
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