Ten-year progression of obesity-related complications in a population with overweight and obesity in the UK: A retrospective open cohort study.

Aim: To assess the prevalence of individual obesity-related complications (ORCs) and multimorbidity (≥ 1, ≥ 2 and ≥ 3 ORCs), and multimorbidity-associated healthcare costs, over 10 years.

Methods: This retrospective open cohort study used Discover, a UK database of linked primary and secondary electronic health records. Adults were stratified by body mass index (BMI; overweight: 25-< 30 kg/m; obesity class I: 30-< 35 kg/m; obesity class II: 35-< 40 kg/m; obesity class III: ≥ 40 kg/m).

Variations in healthcare costs by body mass index and obesity-related complications in a UK population: A retrospective open cohort study.

Aims: To estimate healthcare resource utilization (HCRU) and healthcare costs by body mass index (BMI) in a UK cohort and to explore how this varied by defined BMI strata.

Materials And Methods: This retrospective open cohort study used Discover, a linked primary and secondary electronic health records database covering 2.7 million individuals.

Variations in comorbidity burden in people with type 2 diabetes over disease duration: A population-based analysis of real world evidence.

Background: The prevalence of type 2 diabetes (T2DM) is increasing, but increasing longevity among persons with diagnosed diabetes may be is associated with more extensive and diverse types of morbidity. The extent and breadth of morbidity and how this varies across sub-groups is unclear and could have important clinical and public health implications. We aimed to estimate comorbidity profiles in people with T2DM and variations across sub-groups and over time.