Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens.

DNA gyrase and topoisomerase IV are proven to be validated targets in the design of novel antibacterial drugs. In this study, we report the antibacterial evaluation and molecular docking studies of previously synthesized two series of cyclic diphenylphosphonates (- and -) as DNA gyrase inhibitors. The synthesized compounds were screened for their activity (antibacterial and DNA gyrase inhibition) against ciprofloxacin-resistant and clinical isolates having mutations (deletion and substitution) in QRDR region of DNA gyrase.

Reliability of phenotypic methods for detection of colistin resistance among carbapenem-resistant clinical isolates from Egypt.

Introduction: is a challenging pathogen responsible for serious nosocomial infections. Colistin resistance in carbapenem-resistant strains is a critical health problem as it limits the available therapeutic options. The current work aimed to study the reliability of several phenotypic methods for the detection of colistin resistance among carbapenem-resistant isolates in Egypt.

Molecular Characterization of Carbapenem/Colistin-Resistant Clinical Isolates from Egypt by Whole-Genome Sequencing.

Purpose: The rise of carbapenem-resistant (CRAB) is considered a public health problem limiting the treatment options. Our current work studied the emergence and mechanisms of colistin-resistance among CRAB isolates in Egypt.

Materials And Methods: Seventeen clinically recovered were identified and screened for their antimicrobial susceptibilities using VITEK-2 system.

Combination of Silver Nanoparticles and Vancomycin to Overcome Antibiotic Resistance in Planktonic/Biofilm Cell from Clinical and Animal Source.

This study aims to evaluate the prevalence of multidrug-resistant (MDR) and biofilm-forming pathogens from animal source compared to clinical ones. In addition, to assess the antibacterial and antibiofilm activity of silver nanoparticles (AgNPs) alone and/or mixed with vancomycin. Out of 62 bacterial isolates from animal respiratory tract infection (RTI), 50.