Publications by authors named "Sara Fraietta"
Article Synopsis
- - This study investigates the gene expression differences in first episode psychosis patients compared to healthy controls, focusing on how these differences relate to psychosis symptoms.
- - Using blood samples from 131 patients and 149 healthy individuals, researchers found that 978 genes were differently expressed, with significant pathways linked to immune functions and mitochondria.
- - The findings reveal that positive symptoms of psychosis are related to immune function changes, while negative symptoms are tied to alterations in mitochondrial pathways, highlighting distinct biological processes involved in psychosis.
Schizophrenia is a severe, chronic mental disorder. Schizophrenia is visualized as an accelerated cellular aging syndrome characterized by early onset of cardiovascular disease causing premature mortality. In human aging involves alterations in telomere length (TL).
View Article and Find Full Text PDFLittle is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress. Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12months later.
View Article and Find Full Text PDFBoth substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected.
View Article and Find Full Text PDFBackground: The risk of individuals having adverse effects from drug use (eg, alcohol) generally depends on the frequency of use and potency of the drug used. We aimed to investigate how frequent use of skunk-like (high-potency) cannabis in south London affected the association between cannabis and psychotic disorders.
Methods: We applied adjusted logistic regression models to data from patients aged 18-65 years presenting to South London and Maudsley NHS Foundation Trust with first-episode psychosis and population controls recruited from the same area of south London (UK) to estimate the effect of the frequency of use, and type of cannabis used on the risk of psychotic disorders.