Publications by authors named "Sara Fierstein"

Acute myeloid leukemia (AML) shows variable clinical outcome. The normal hematopoietic cell of origin impacts the clinical behavior of AML, with AML from hematopoietic stem cells (HSCs) prone to chemotherapy resistance in model systems. However, the mechanisms by which HSC programs are transmitted to AML are not known.

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Multiple myeloma (MM) is an incurable hematological malignancy characterized by the clonal proliferation of malignant plasma cells. Despite the development of a diverse array of targeted drug therapies over the last decade, patients often relapse and develop refractory disease due to multidrug resistance. Obesity is a growing public health threat and a risk factor for multiple myeloma, although the mechanisms by which obesity contributes to MM growth and progression have not been fully elucidated.

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Article Synopsis
  • Many inherited bone marrow failure syndromes (IBMFSs) increase the risk of developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly in the context of Fanconi anemia (FA).
  • Researchers conducted gene editing on human stem cells to study mutations in MDS-related genes, revealing issues with stem cell self-renewal and differentiation linked to RUNX1 mutations.
  • The findings suggest that RUNX1 mutations disrupt the cell cycle's response to DNA damage and activate immune signaling, providing a potential treatment target for restoring sensitivity to therapies in FA-associated MDS.
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Endothelial cell tube formation assay is one of the most widely used and reliable methods for studying in vitro angiogenesis. Endothelial cells plated over a basement membrane extract and subjected to angiogenic factors in conditioned medium, form a rapid and quantifiable tube network within hours. Tube formation is sustained for 18-24 h, after which time apoptosis occurs and tube networks disintegrate.

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Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer in the United States, affecting one million people per year. Patients with aggressive disease have limited treatment options and high mortality, highlighting the need to identify new biomarkers linked to poor clinical outcome. HRAS mutations are found in skin papillomas and cSCCs and increase in frequency when MAP3K family members are inhibited, suggesting a link between blockade of mitogen-activated protein kinase (MAPK) signaling and initiation of RAS-primed cells.

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