Publications by authors named "Sara Fakhretaha-Aval"
Widespread testing for the presence of the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals remains vital for controlling the COVID-19 pandemic prior to the advent of an effective treatment. Challenges in testing can be traced to an initial shortage of supplies, expertise, and/or instrumentation necessary to detect the virus by quantitative RT-PCR (RT-qPCR), the most robust, sensitive, and specific assay currently available. Here we show that academic biochemistry and molecular biology laboratories equipped with appropriate expertise and infrastructure can replicate commercially available SARS-CoV-2 RT-qPCR test kits and backfill pipeline shortages.
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- - The ribosome's common core, made up of rRNA and ribosomal proteins, links all living organisms to a shared ancestor, with its rRNA closely resembling that of modern bacteria; in eukaryotes, this rRNA is much larger due to additional segments.
- - The study reveals that two groups of archaea, Lokiarchaeota and Heimdallarchaeota, have ribosomal RNA that serves as a transition between prokaryotes and eukaryotes, featuring two significant expansion segments (ES9 and ES39) that contribute to their large size.
- - Through experimental analyses, researchers found unique structural features in Asgard ES39s compared to eukaryotic ES39s, while still demonstrating
Widespread testing for the presence of the novel coronavirus SARS-CoV-2 in individuals remains vital for controlling the COVID-19 pandemic prior to the advent of an effective treatment. Challenges in testing can be traced to an initial shortage of supplies, expertise and/or instrumentation necessary to detect the virus by quantitative reverse transcription polymerase chain reaction (RT-qPCR), the most robust, sensitive, and specific assay currently available. Here we show that academic biochemistry and molecular biology laboratories equipped with appropriate expertise and infrastructure can replicate commercially available SARS-CoV-2 RT-qPCR test kits and backfill pipeline shortages.
View Article and Find Full Text PDF