Stereotactic body radiation therapy (SBRT) for prostate cancer: Improving treatment delivery efficiency and accuracy.

Purpose: In stereotactic body radiation therapy (SBRT) for prostate cancer, intrafraction motion is an important source of treatment uncertainty as it could not be completely smoothed through fractionation. Herein, we compared different arrangements and beam qualities for extreme hypofractionated treatments to minimize beam delivery time and so intrafractional errors.

Methods: A retrospective dataset of 11 patients was used.

Naturalistic Object Representations Depend on Distance and Size Cues.

Unlabelled: Egocentric distance and real-world size are important cues for object perception and action. Nevertheless, most studies of human vision rely on two-dimensional pictorial stimuli that convey ambiguous distance and size information. Here, we use fMRI to test whether pictures are represented differently in the human brain from real, tangible objects that convey unambiguous distance and size cues.

Full-Dose Intraoperative Electron Radiotherapy for Early Breast Cancer: Evidence from a Single Center's Experience.

To evaluate the clinical response rate and cosmetic outcome after full-dose intraoperative electron radiotherapy (IOERT) in early breast cancer (BC) treated with conserving surgery. Inclusion criteria were: >60 years old, clinical tumor size ≤2 cm, luminal A carcinoma, patological negative lymph nodes, excluded lobular carcinoma histology. IOERT was delivered with a dose of 21 Gy at 90% isodose.

Dosimetric characterization of a mobile accelerator dedicated for intraoperative radiation therapy: Monte Carlo simulations and experimental validation.

Purpose: This Technical Note validates previously published data about the dosimetry of the electron beams produced by a mobile accelerator dedicated for intraoperative radiation therapy (IORT). The evaluation of the directional response of a PTW microDiamond detector is presented together with a detailed analysis of the output factors (OFs) for bevelled applicators.

Methods: The OFs of the 6, 8, 10 and 12 MeV electron beams produced by a light intraoperative accelerator (LIAC, SIT, Italy) were measured in a commercial water phantom using the microDiamond.

"My Life during the Lockdown": Emotional Experiences of European Adolescents during the COVID-19 Crisis.

This study investigates, using an online self-report questionnaire, adolescents' emotional reactions during the lockdown in a sample of 2105 secondary school students (aged 14-19) in Italy, Romania, and Croatia. We used a self-reported online questionnaire (answers on a 5-point scale or binary), composed of 73 questions investigating the opinions, feelings, and emotions of teenagers, along with sociodemographic information and measures of the exposure to lockdown. The survey was conducted online through a web platform in Italy (between 27 April and 15 June 2020), Romania, and Croatia (3 June and 2 July 2020).

Object responses are highly malleable, rather than invariant, with changes in object appearance.

Theoretical frameworks of human vision argue that object responses remain stable, or 'invariant', despite changes in viewing conditions that can alter object appearance but not identity. Here, in a major departure from previous approaches that have relied on two-dimensional (2-D) images to study object processing, we demonstrate that changes in an object's appearance, but not its identity, can lead to striking shifts in behavioral responses to objects. We used inverse multidimensional scaling (MDS) to measure the extent to which arrangements of objects in a sorting task were similar or different when the stimuli were displayed as scaled 2-D images, three-dimensional (3-D) augmented reality (AR) projections, or real-world solids.

Directional tuning for eye and arm movements in overlapping regions in human posterior parietal cortex.

A network of frontal and parietal regions is known to be recruited during the planning and execution of arm and eye movements. While movements of the two effectors are typically coupled with each other, it remains unresolved how information is shared between them. Here we aimed to identify regions containing neuronal populations that show directional tuning for both arm and eye movements.

Flexible Visuomotor Associations in Touchscreen Control.

To move real objects, our hand needs to get in direct physical contact with the object. However, this is not necessarily the case when interacting with virtual objects, for example when displacing objects on tablets by swipe movements. Here, we performed two experiments to study the behavioral strategies of these movements, examining how visual information about the virtual object is mapped into a swipe that moves the object into a goal location.

Disentangling Representations of Object and Grasp Properties in the Human Brain.

Unlabelled: The properties of objects, such as shape, influence the way we grasp them. To quantify the role of different brain regions during grasping, it is necessary to disentangle the processing of visual dimensions related to object properties from the motor aspects related to the specific hand configuration. We orthogonally varied object properties (shape, size, and elongation) and task (passive viewing, precision grip with two or five digits, or coarse grip with five digits) and used representational similarity analysis of functional magnetic resonance imaging data to infer the representation of object properties and hand configuration in the human brain.

Increased incidence of childhood leukemia in urban areas: a population-based case-control study.

Objective: We carried out a population-based case-control study to assess the possibility of an excess risk of childhood leukemia in urban areas, independently from road traffic pollution.

Methods: Study subjects were the 111 cases of childhood leukemia diagnosed from 1998 to 2011 among residents of two provinces of the northern Italian Emilia-Romagna region, and 444 controls matched by age and sex. Through mapping of the region carried out by remote sensing, we examined the percentage of urban or rural area in the 100-meter circular buffer around each child's house.

Overlapping representations for grip type and reach direction.

To grasp an object, we need to move the arm toward it and assume the appropriate hand configuration. While previous studies suggested dorsomedial and dorsolateral pathways in the brain specialized respectively for the transport and grip components, more recent studies cast doubt on such a clear-cut distinction. It is unclear, however, to which degree neuronal populations selective for the two components overlap, and if so, to which degree they interact.

Cross-modal plasticity preserves functional specialization in posterior parietal cortex.

In congenitally blind individuals, many regions of the brain that are typically heavily involved in visual processing are recruited for a variety of nonvisual sensory and cognitive tasks (Rauschecker 1995; Pascual-Leone et al. 2005). This phenomenon-cross-modal plasticity-has been widely documented, but the principles that determine where and how cross-modal changes occur remain poorly understood (Bavelier and Neville 2002).

The role of numerosity in processing nonsymbolic proportions.

The difficulty in processing fractions seems to be related to the interference between the whole-number value of the numerator and the denominator and the real value of the fraction. Here we assess whether the reported problems with symbolic fractions extend to the nonsymbolic domain, by presenting fractions as arrays of black and white dots representing the two operands. Participants were asked to compare a target array with a reference array in two separate tasks using the same stimuli: a numerosity task comparing just the number of white dots in the two arrays; and a proportion task comparing the proportion of black and white dots.

Distributed sensitivity for movement amplitude in directionally tuned neuronal populations.

Neurons in macaque primary motor cortex and dorsal premotor cortex are tuned to movement direction. In humans, neuronal populations tuned to movement direction have recently been described using multivoxel pattern analysis and functional magnetic resonance imaging adaptation. It is unclear, however, to what extent directionally tuned neuronal populations are sensitive to movement amplitude.

Tuning curves for movement direction in the human visuomotor system.

Neurons in macaque primary motor cortex (M1) are broadly tuned to arm movement direction. Recent evidence suggests that human M1 contains directionally tuned neurons, but it is unclear which other areas are part of the network coding movement direction and what characterizes the responses of neuronal populations in those areas. Such information would be highly relevant for the implementation of brain-computer interfaces (BCIs) in paralyzed patients.

The mental representation of numerical fractions: real or integer?

Numerical fractions are commonly used to express ratios and proportions (i.e., real numbers), but little is known about how they are mentally represented and processed by skilled adults.