Publications by authors named "Sara F Costa"
Article Synopsis
- For years, scientists believed Gram-positive bacteria had no specialized machinery for elongation, but recent findings reveal they can elongate using a pair of proteins called SEDS and PBP during cell division.
- Researchers utilized the Nebraska Transposon Mutant Library to discover additional proteins, including GpsB, SsaA, and RodZ, that assist in the elongation process.
- GpsB specifically helps regulate the positioning of other penicillin-binding proteins (PBP2 and PBP4) at the cell division site, crucial for maintaining the correct shape and function of the bacteria, particularly important due to the rising threat of antibiotic-resistant infections.
The bacterial divisome is a macromolecular machine composed of more than 30 proteins that controls cell wall constriction during division. Here, we present a model of the structure and dynamics of the core complex of the E. coli divisome, supported by a combination of structure prediction, molecular dynamics simulation, single-molecule imaging, and mutagenesis.
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