Palladium Catalyst with Task-Specific Ionic Liquid Ligands: Intracellular Reactions and Mitochondrial Imaging with Benzothiadiazole Derivatives.

A water-soluble and charge-tagged palladium complex (PdMAI) was found to function inside breast cancer live cells of the MCF-7 lineage as an efficient catalyst for cross-coupling reaction. PdMAI, bearing two ionophilic task-specific ionic liquids as ligands, efficiently catalyzed both in cellulo Suzuki and Buchwald-Hartwig amination reactions. For the first time, therefore, the Buchwald-Hartwig amination is described to occur inside the highly complex cellular environment.

Theoretical and Experimental Investigation of Acidity of the Glutamate Receptor Antagonist 6,7-Dinitro-1,4-dihydroquinoxaline-2,3-dione and Its Possible Implication in GluA2 Binding.

The acidity of organic compounds is highly relevant to understanding several biological processes. Although the relevance and challenges in estimating pK values of organic acids is recognized by several reported works in the literature, there is a lack in determining the acidity of amides. This paper presents an experimental/theoretical combined investigation on the acid dissociation of the compound 6,7-dinitro-1,4-dihydroquinoxaline-2,3-dione (DNQX), a well-established antagonist of ionotropic glutamate receptor GluA2.

Di-μ-chlorido-bis-{[2-({[2-(2-pyrid-yl)eth-yl](2-pyridylmeth-yl)amino}meth-yl)phenol]zinc(II)} bis-(perchlorate) dihydrate.

The title compound, [Zn(2)Cl(2)(C(20)H(21)N(3)O)(2)](ClO(4))(2)·2H(2)O, consists of a dinuclear Zn(II) cationic complex, two disordered perchlorate anions and two water mol-ecules as solvate. The [Zn(2)(μ-Cl)(2)(HL)(2)](2+ )cation [HL is 2-({[2-(2-pyrid-yl)eth-yl](2-pyridylmeth-yl)amino}meth-yl)phenol] has a centrosymmetric structure with the Zn(II) ions in a distorted octa-hedral environment surrounded by an N(3)OCl(2) donor set. HL acts as a tetra-dentate ligand through three N atoms from one amine group and two pyridyl arms and one O atom from the phenolic arm.