Publications by authors named "Sara E Boyd"

Article Synopsis
  • - This study investigates the current legality and practices of online pharmacies selling antibiotics in the UK, noting a shift from mostly consumer-driven decisions in 2016 to more regulated practices now.
  • - The research involved analyzing 20 online pharmacy websites for evidence of registration, prescription requirements, and information provided to consumers regarding their health before purchasing antibiotics.
  • - Findings show that while all analyzed pharmacies require a prescription and are registered in the UK, there are still significant variations in how consumer-driven these choices are, presenting a need for better regulations and guidelines in online antibiotic sales.
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  • The BIOFIRE Joint Infection (JI) Panel uses multiplex-PCR testing to identify microorganisms in synovial fluid from patients suspected of septic arthritis and prosthetic joint infections.
  • A study over 34 clinical sites in Europe and the Middle East indicated that the JI Panel showed 88.4% agreement in diagnosing septic arthritis and 85% for prosthetic joint infections when compared to traditional synovial fluid cultures.
  • The JI Panel not only detected more positive samples, especially anaerobic bacteria, but also provided results in about one hour, improving patient management and treatment decisions.
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Rapidly detecting and identifying pathogens is crucial for appropriate antimicrobial therapy in patients with sepsis. Conventional diagnostic methods have been a great asset to medicine, though they are time consuming and labor intensive. This work will enable healthcare professionals to understand the bacterial community better and enhance their diagnostic capacity by using novel molecular methods that make obtaining quicker, more precise results possible.

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Human conflict, such as the ongoing conflict in Ukraine, is an important driver of antimicrobial resistance. Here, we describe the challenges when addressing this problem during an ongoing conflict and the opportunities available to reduce the spread of antimicrobial resistance.

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Article Synopsis
  • Septic arthritis is a severe illness often diagnosed through culture, but the recently approved BioFire® Joint Infection Panel (BJIP) offers a rapid alternative using synovial fluid.
  • A study in the UK and Ireland showed that BJIP had a higher detection rate of positive results (98 vs 83) compared to routine cultures, with a positive percent agreement (PPA) of 91.6% and negative percent agreement (NPA) of 93%.
  • The multidisciplinary team (MDT) discussed the BJIP's additional benefits, such as identifying antibiotic resistance and influencing treatment choices, while noting that it should complement standard methods and may have limitations regarding untested organisms.
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  • Modern medicine faces a serious threat from antimicrobial resistance, particularly with Gram-negative bacteria, where β-lactamases, such as TEM penicillinases and CTX-M, limit the effectiveness of antibiotics like penicillin and cephalosporins.
  • The emergence of the OXA-48 carbapenemase and its relatives has become a major concern in Europe and surrounding regions, leading to underreported low-level resistance and treatment failures.
  • There are challenges in detecting these enzymes, but potential treatment solutions are being explored, including new agents like ceftazidime-avibactam and cefiderocol, as researchers work to tackle this growing problem in antibiotic resistance.
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  • Clinical metagenomics (CMg) could enhance antimicrobial treatment and infection control, especially highlighted by the SARS-CoV-2 pandemic, which increased risks of infections from drug-resistant pathogens in ICUs.
  • A study involving 43 respiratory samples from intubated COVID-19 patients showed that an 8-hour CMg workflow was 92% sensitive and 82% specific in identifying bacteria, while also detecting antibiotic-resistant genes that could change treatment plans.
  • CMg testing allows for timely pathogen detection and resistance predictions, suggesting it could transform infection management in ICUs and warrants further clinical evaluation for broader implementation.
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  • The Singapore GSDCS score helps predict the risk of multidrug-resistant Gram-negative bacilli infections in critically ill patients and was validated in a UK intensive care setting.
  • A study matched 110 patients with RGNB infections to 110 patients with sensitive Gram-negative infections, demonstrating the score's effectiveness with a receiver operating characteristic curve of 0.75.
  • The score effectively categorized patients into low, medium, and high-risk groups for RGNB infections, aiding in timely and appropriate antimicrobial therapy in the ICU.
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  • - The rise of antibiotic resistance, particularly from Gram-negative bacteria and Metallo-β-lactamase (MBL) enzymes, poses a major threat to modern medicine, especially in Asia where these strains are common.
  • - MBLs not only show multiple drug resistance but might also be less effective against carbapenem antibiotics when zinc is limited, creating a potential opportunity for therapy.
  • - The unique structure and function of MBLs complicate drug development, as they resist current β-lactam inhibitor treatments; however, promising new therapies and inhibitors are in progress.
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  • To tackle antibiotic resistance, it's important to analyze the quality and quantity of data linking various sources—human, animal, and environmental—that contribute to the issue.
  • A systematic review using a One Health approach found 88 key risk factors, with previous antibiotic exposure, underlying diseases, and invasive procedures showing the strongest links to resistance.
  • Uniform quantification of these risk factors will enhance researchers' understanding of how antibiotic resistance develops in human infections, particularly through food and water transmission.
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  • Bronchoalveolar lavage (BAL) and microdialysis are leading methods for measuring how much antibiotics reach the lungs, especially in pneumonia treatment.
  • Understanding the amount of drug at the infection site is crucial for ensuring that the right dosages lead to effective clinical outcomes for different types of pneumonia.
  • Despite limited studies on the intrapulmonary effects of antibiotics, newer technologies like MALDI-MSI and PET imaging could improve future research and the antibiotic development process for pneumonia.
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  • A study analyzed the quality and legality of online pharmacies selling antibiotics in the UK, especially in light of increased internet use and antibiotic stewardship efforts.
  • Out of 20 online pharmacies reviewed, only 5 required a prescription and were properly registered, while others had unclear practices regarding prescription requirements and safety measures.
  • The findings indicate significant variations in antibiotic purchasing practices online, raising concerns about patient safety and the need for stricter regulations and better education for both suppliers and consumers.
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  • * A study of 42 commonly prescribed antibiotics in the UK found that 83% had no dosing guidance for obese adults, raising concerns about treatment effectiveness and the risk of antibiotic resistance.
  • * There's an urgent need for more research and guidelines on antibiotic dosing in obese populations to improve healthcare outcomes and combat growing antibiotic resistance.
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Introduction: While indoor smoking bans reduce employee tobacco use, less is known about whether comprehensive bans, which prohibit smoking in both indoor and outdoor areas, are associated with lower rates of tobacco use than indoor-only bans.

Methods: This study integrated data collected via mailed surveys from 1,910 substance abuse treatment counselors and telephone interviews with 417 administrators of substance abuse treatment organizations. Multinomial logistic regression was used to estimate the associations between counselors' self-reported tobacco use and administrators' reports about organizational smoking bans while controlling for counselors' professional and demographic characteristics.

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An interactive, virtual-patient module was produced on compact disc (CD-ROM) in response to the critical need to increase dental students' clinical exposure to patients with developmental disabilities. A content development team consisting of dental faculty members, parents of children with developmental disabilities, an individual with a developmental disability, and educational specialists developed the interactive, virtual-patient module. The module focused on a young man with congenital deafblindness presenting as a new patient with a painful molar.

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A multimedia virtual patient module, involving the case of a young woman with mild intellectual disabilities with a complaint of diffuse abdominal pain, was developed as a clinical training tool for students in health care professions. Primary objectives following use of the module included improved knowledge and reduced perception of difficulty in treating women's health patients with intellectual disabilities. The module was developed using an iterative, collaborative process of a core development team that included medical professionals, multimedia specialists, the parent of a child with intellectual disability, and a disability advocate.

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Nurses play a vital role in providing health care to children with developmental disability (DD) throughout the United States. Unfortunately, most nurses continue to report that they receive little or no clinical education in the area of DDs. In response to this need, a core development team consisting of nurse practitioners and nursing faculty from three universities, one physician assistant faculty, parents of children with DD, and educational specialists developed two multimedia (virtual patient) pediatric instructional modules in CD-ROM format--one involving a child with Down syndrome, and the other involving an infant born at 26 weeks' gestation.

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