Publications by authors named "Sara Dubbury"
RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 () is mutated in melanoma, and patient-mutated accelerates zebrafish melanoma.
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- The study investigates how the BRCA deficiency and PARP inhibitors (PARPis) interact, revealing that PARPis are effective in both BRCA-mutated and non-BRCA mutated tumors due to different mechanisms of action.
- It highlights that resistance to PARPis like Talazoparib develops, especially in non-BRCA mutated tumors, and explores the role of the SNAI2 transcription factor linked to the epithelial-mesenchymal transition (EMT) in this resistance.
- The research suggests that targeting the PARP1/CHD1L/SNAI2 pathway may help overcome resistance and enhance the effectiveness of Talazoparib in treating non-BRCA mutated tumors.
Mutations that attenuate homologous recombination (HR)-mediated repair promote tumorigenesis and sensitize cells to chemotherapeutics that cause replication fork collapse, a phenotype known as 'BRCAness'. BRCAness tumours arise from loss-of-function mutations in 22 genes. Of these genes, all but one (CDK12) function directly in the HR repair pathway.
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