Publications by authors named "Sara Cristina Sagae Schneider"
An Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to the MSG-Induced Obesity Model.
Int J Mol Sci
March 2023
The model of obesity induced by monosodium glutamate cytotoxicity on the hypothalamic nuclei is widely used in the literature. However, MSG promotes persistent muscle changes and there is a significant lack of studies that seek to elucidate the mechanisms by which damage refractory to reversal is established. This study aimed to investigate the early and chronic effects of MSG induction of obesity upon systemic and muscular parameters of Wistar rats.
View Article and Find Full Text PDFWhole-Body Vibration Promotes Skeletal Muscle Restructuring and Reduced Obesogenic Effect of MSG in Wistar Rats.
Appl Biochem Biotechnol
August 2022
Article Synopsis
- - The study addresses the negative impacts of obesity on the locomotor system, which is increasingly common in Western societies due to rising rates of obesity and metabolic syndrome.
- - Whole-body vibration is highlighted as an effective and accessible form of exercise that can aid in the rehabilitation of obesity, particularly in a model induced by monosodium glutamate.
- - Key findings indicate that vibration therapy not only helps to reduce obesity-related issues and improve lipid profiles in the animals but also contributes to the recovery of muscle structure and oxidative capacity affected by obesity.
Article Synopsis
- Tamoxifen is a breast cancer treatment for postmenopausal women but can cause high blood sugar (hyperglycemia) by disrupting mitochondrial metabolism.
- Quercetin, a natural antioxidant, may help mitigate the negative effects of tamoxifen, such as abnormal glucose levels in various parts of the brain.
- This study involved treating ovariectomized female rats with tamoxifen and quercetin to analyze their effects on glucose and other metabolic markers, finding that quercetin effectively reduced the hyperglycemic response triggered by tamoxifen.
Alterations in neuromuscular junctions and oxidative stress of the soleus muscle of obese Wistar rats caused by vibratory platform training.
J Musculoskelet Neuronal Interact
December 2020
Objectives: evaluate the effects that whole-body vibration (WBV) causes on the neuromuscular junctions and oxidative stress of the soleus muscle of obese rats.
Methods: 32 male rats were used, 16 of which were obesity induced by monosodium glutamate, randomized into four groups: control (GC), control with WBV (GCP), obese (GO) and obese with WBV (GOP). At the 70 days old, the training on WBV was started, performed 3 times a week, during 8 consecutive weeks.
Objectives: This study aimed to analyze the effect of whole-body vibration (WBV) on metabolic parameters using the monosodium l-glutamate (MSG) model of obesity.
Method: MSG-obese rats that were exposed to WBV on a vibrating platform with 60 Hz frequency, 2 mm amplitude, three times/week, 10 min/day, during eight weeks (from postnatal day (PN) 80 to PN136). Blood glucose, creatine kinases (CK and CK-MB) and lipid profile through plasma and liver levels of lipids and lipoproteins were evaluated.