Synthesis of carbon-11 radiolabelled transition metal complexes using C-dithiocarbamates.

A novel radiolabelling method exploiting C-dithiocarbamate ligands has been used to generate C-labelled Au(I), Au(III), Pd(II) and Pt(II) complexes in high radiochemical yields (71-99%). Labelled complexes were prepared in a rapid one-pot procedure the substitution reaction of C-dithiocarbamate ligands with appropriate transition metal chloride precursors.

Direct incorporation of [F] into Aliphatic Systems: A promising Mn-catalysed Labelling Technique for PET Imaging.

Background: One of the challenges in positron emission tomography (PET) is labelling complex aliphatic molecules.

Objective: This study aimed to develop a method of metal-catalysed radiofluorination that is site-selective and works in moderate to good yields under facile conditions.

Methods: Herein, we report on the optimisation of an aliphatic C-H to C-F bond transformation catalysed by a Mn(porphyrin) complex.

Ammonium [C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling.

Herein we report the preparation of ammonium [C]thiocyanate the reaction of [C]CS with ammonia. The [C]SCN ion is demonstrated as a potent nucleophile that can be used to readily generate a range of C-labelled thiocyanate molecules in high conversions. Furthermore, novel C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones an acid mediated cyclisation reaction.