Publications by authors named "Sara C Sprague"
Gastroenterology
March 2021
Article Synopsis
- - The study focuses on pancreatic ductal adenocarcinomas (PDACs), highlighting the role of cancer-associated fibroblasts (CAFs) and the adhesion molecule CDH11, which is linked to fibrosis and is overexpressed in activated fibroblasts involved in cancer progression.
- - Researchers compared CDH11 expression levels in pancreatic tissues from different conditions, performed genetic crosses in mice, and analyzed survival rates and tumor growth in various experimental setups, including treatments with PD1 antibody and gemcitabine.
- - Results showed significantly higher CDH11 levels in CAFs than in other cells, and knocking out CDH11 in model mice led to prolonged survival and differences in tumor characteristics, indicating that targeting CDH
View Article and Find Full Text PDF