Evaluation of an extractionless high-performance liquid chromatography-tandem mass spectrometry method for detection and quantitation of rosiglitazone in canine plasma.

Objective: To develop a simple extractionless method for detection of rosiglitazone in canine plasma and test the method in a pharmacokinetic study after oral administration of rosiglitazone in dogs.

Animals: 3 client-owned dogs with cancer.

Procedures: High-performance liquid chromatography-tandem mass spectrometry was performed on canine plasma.