Gold/platinum nanorods/temozolomide-UiO-66-NH metal-organic frameworks incorporated to chitosan-grafted polycaprolactone/polycaprolactone core-shell nanofibers for glioblastoma treatment during chemo-photothermal therapy.

The use of biocompatible metal-organic frameworks (MOFs) and electrospun nanofibrous implants shows promise in preventing the recurrence of postsurgical glioblastoma. In this study, temozolomide (TMZ) and platinum‑gold nanorods (PtAu NRs) were encapsulated into the UiO-66-NH MOFs. These were then incorporated into the chitosan-grafted polycaprolactone (PCL) (core)/PCL (shell) nanofibers coated with PtAu NRs for extended release of TMZ during chemo-photothermal therapy against glioblastoma cells.