Severe 2009 A/H1N1v influenza in pregnant women in Spain.

Objectives: To describe the severity of the 2009 influenza A/H1N1v illness among pregnant women admitted to Spanish intensive care units.

Design And Patients: Prospective, observational, multicenter study conducted in 148 Spanish intensive care units. We reviewed demographic and clinical data from the Spanish Society of Intensive Care Medicine database reported from April 23, 2009, to February 15, 2010.

Host adaptive immunity deficiency in severe pandemic influenza.

Introduction: Pandemic A/H1N1/2009 influenza causes severe lower respiratory complications in rare cases. The association between host immune responses and clinical outcome in severe cases is unknown.

Methods: We utilized gene expression, cytokine profiles and generation of antibody responses following hospitalization in 19 critically ill patients with primary pandemic A/H1N1/2009 influenza pneumonia for identifying host immune responses associated with clinical outcome.