In silico evaluation of phenolic compounds as inhibitors of Α-amylase and Α-glucosidase.

The aim of the present study focuses on the molecular docking approach to screen alternative drug that can regulate the hyperglycemia by down-regulating α-glucosidase and α-amylase activity using phenolic compounds: tannic acid (L1), catechin (L2), gallic acid (L3), quercetin (L5) and epicatechin (L6). L1 gives the best docking scores, its interaction with α-amylase and α-glucosidase has the lowest energy score compared to the other complexes and to the acarbose (L4). L1 forms strong five H-donor interactions with residues of active site of α-amylase and three H-donor interactions with α-glucosidase.

Antioxidant activity and phenolic compounds identification of (Desf.) Benth. from Western Algeria.

(Desf.) Benth. is most studied for the antimicrobial activity of their essential oils; nevertheless there are no reports on the phenolic compounds of this species and their antioxidant activity.