Publications by authors named "Sara Addakiri"
Background: Acute lymphoblastic leukemia (ALL) encompasses a group of lymphoid neoplasms that morphologically and immunophenotypically resemble B-lineage and T-lineage precursor cells. Our objective is to describe the immunophenotypic aspects of acute lymphoblastic leukemia (All) diagnosed by flow cytometry at the hematology laboratory of IBN ROCHD University Hospital Center and to compare them with those reported in other series.
Methods: This is a descriptive study over a period from August 2016 to October 2021, during a 5 year-and-2-month period.
Article Synopsis
- The study focuses on assessing minimal residual disease (MRD) in acute myeloid leukemia (AML) patients and analyzing the FLT3/ITD gene in those with normal karyotypes after achieving complete remission (CR).
- Out of 30 adult patients, a large percentage had an intermediate risk status, where MRD and leukemic stem cell (LSC) positivity were prevalent, indicating a higher chance of relapse.
- The findings suggest that MRD and LSC are crucial indicators for predicting relapse in AML patients and should be used regularly to improve treatment strategies.
Background: Aberrant phenotypes in acute myeloid leukemia have variable frequencies and their prognostic value with adverse hematological and other biological prognostic factors is still controversial, despite several reports of clinical significance. To date, no study has been reported evaluating the incidence of these phenotypic aberrations in the Moroccan population. The aim is to evaluate the incidence of aberrant phenotype expressions in acute myeloid leukemia and correlate their presence with the different AML subtypes, and clinical and biological characteristics in Moroccan patients.
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