Publications by authors named "Sara A Stuedemann"
Article Synopsis
- Mechanosensitive neurons play a crucial role in sensing bladder stretching, but their involvement in urologic diseases is not well understood, especially regarding CGRP-negative mechanoreceptors.
- A study found a significant number of bladder nerve fibers that are NFH-positive but CGRP-negative, indicating potential unexplored mechanoreceptors.
- By using genetic strategies to label these mechanoreceptors, researchers demonstrated that TrkB neurons are essential for bladder mechanosensation, as the absence of these neurons increased the pressure required for voiding and led to non-voiding contractions after bladder distention.
Regenerative therapies aimed at replacing photoreceptors are a promising approach for the treatment of otherwise incurable causes of blindness. However, such therapies still face significant hurdles, including the need to improve subretinal delivery and long-term survival rate of transplanted cells, and promote sufficient integration into the host retina. Here, we successfully delivered in vitro-derived human photoreceptor precursor cells (PRPCs; also known as immature photoreceptors) to the subretinal space of seven normal and three rcd1/PDE6B mutant dogs with advanced inherited retinal degeneration.
View Article and Find Full Text PDFStem cell-based transplantation therapies offer hope for currently untreatable retinal degenerations; however, preclinical progress has been largely confined to rodent models. Here, we describe an experimental platform for accelerating photoreceptor replacement therapy in the nonhuman primate, which has a visual system much more similar to the human. We deployed fluorescence adaptive optics scanning light ophthalmoscopy (FAOSLO) to noninvasively track transplanted photoreceptor precursors over time at cellular resolution in the living macaque.
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