Publications by authors named "Sara A Rubin"
Article Synopsis
- * Researchers used single-cell RNA sequencing on around 70,000 zebrafish cells to map immune cell development and found significant cellular diversity, especially in juvenile and adult thymus.
- * The study identified different immune cell types, including B- and T-cells, and suggested the presence of a pre-B cell state, laying important groundwork for future studies in zebrafish immunology.
Article Synopsis
- Self-non-self discrimination is a key part of how T cells work in our immune system.
- A specific process involving a protein called LAT and a part of it called Y132 is really important for T cells to tell the difference between what’s friendly and what’s harmful.
- Changing a nearby part of LAT can speed up this process, making T cells better at responding to weaker signals, which helps them act more accurately when fighting infections.
Glycolysis plays a central role in producing ATP and biomass. Its control principles, however, remain incompletely understood. Here, we develop a method that combines H and C tracers to determine glycolytic thermodynamics.
View Article and Find Full Text PDFIn metabolism, available free energy is limited and must be divided across pathway steps to maintain a negative ΔG throughout. For each reaction, ΔG is log proportional both to a concentration ratio (reaction quotient to equilibrium constant) and to a flux ratio (backward to forward flux). Here we use isotope labeling to measure absolute metabolite concentrations and fluxes in Escherichia coli, yeast and a mammalian cell line.
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