Publications by authors named "Sara A Marullo"
Article Synopsis
- RAF family kinases play crucial roles in cancer, but their activation requires dimerization, complicating drug development.
- KSR1 and KSR2 are pseudokinases that can dimerize with RAF kinases, enhancing their activity, but the mechanisms behind this interaction remain unclear due to KSR's lack of a RAS-binding domain.
- New findings reveal that BRAF and KSR1 specifically heterodimerize through their regulatory regions, with MEK binding driving this interaction and boosting BRAF's catalytic activity, challenging traditional views of KSR's role as merely a scaffold.
