Characterization of Lemongrass Extract (Cymbopagon citratus) Nanoemulsion and Its Application as an Antibiofilm Agent in Acrylic Resin.

Background: An antimicrobial agent is needed for denture cleaning, such as lemongrass (LG), which has a bioactive antimicrobial component.

Methods: This research analyzed LG extract nanoparticles with a particle size analyzer, ZPA, and biofilm formation inhibition on resin acrylic surfaces.

Results: We found that there is high stability in nanoparticle size, while other concentrations, including chlorhexidine as a positive control, did not show any statistical differences.

Chlorogenic acid ameliorates memory dysfunction via attenuating frontal lobe oxidative stress and apoptosis in diabetic rat model.

Background/aim: Diabetes mellitus, characterized by hyperglycemia, causes various complications, one of which is memory dysfunction. The frontal lobe is known to be responsible for impaired memory function due to hyperglycemia and is associated with oxidative stress-mediated neuronal cell apoptosis. Chlorogenic acid (CGA) is reported to have neuroprotective effects.

4-Propyl- and 4-phenylcoumarins from T. Anderson and their cytotoxic activity.

Two new 4-phenylcoumarins, mesulepidotins A () and B (), one new 4-propylcoumarin, mesulepidotin C (), and one known 4-phenylcoumarin () were isolated from stem barks. The structures of 4-propyl- and 4-phenylcoumarins were identified by analysing 1D and 2D NMR spectra combined with high-resolution ESIMS data. Compounds were assayed to MCF-7 and HeLa cells for their cytotoxic activity.

Three novel dihydrochalcones from (L.) W.T. Aiton and their antiplasmodial activity.

Three novel dihydrochalcones, flemilineatins C-E (), and two known flavanones () were isolated from (L.) W.T.

Dihydrostilbenes from (Blume) Müll. Arg. and their antiplasmodial activity.

An undescribed dihydrostilbene, macajavanicin D (), and three known analogs, malayheyneiin A () and laevifolins A-B (-), were isolated from (Blume) Müll. Arg. leaves.

Chlorogenic Acid Inhibits Progressive Pulmonary Fibrosis in a Diabetic Rat Model.

Background: Chlorogenic acid (CGA) is known to have antifibrotic and hypoglycemic effects and may play a role in preventing diabetes-induced pulmonary fibrosis. This study aimed to determine the effect and optimum dose of CGA on diabetes-induced pulmonary fibrosis.

Methods: Thirty Wistar rats (two-month-old, 150-200 grams) were randomly divided into six groups, namely control, six weeks diabetes mellitus (DM1), eight weeks DM (DM2), and three DM2 groups (CGA1, CGA2, and CGA3) who received CGA doses of 12.

Three new dihydrochalcones from the leaves of Jarrett and their activity against .

Three new dihydrochalcones: artoserichalcone A-C (), were isolated from the leaves of . The structures of compounds were determined based on NMR spectrum (H, C, and 2D) and HRESIMS spectroscopic analysis. Compounds () and () showed active antimalarial activity with IC values of 16.

Two new flavonols from pax & K.Hoffm.

Four isoprenylated flavonols, including two new compounds, macainermisins A-B (-), and two known compounds, sinoflavonoid P (), broussoflavonol F (), were isolated from the leaves of . A combination of HRESIMS, UV, 1D, and 2D NMR spectra elucidated the structures of -. Flavonols (-) were evaluated against three cancer cells.

Polymeric Scaffolds Used in Dental Pulp Regeneration by Tissue Engineering Approach.

Currently, the challenge in dentistry is to revitalize dental pulp by utilizing tissue engineering technology; thus, a biomaterial is needed to facilitate the process. One of the three essential elements in tissue engineering technology is a scaffold. A scaffold acts as a three-dimensional (3D) framework that provides structural and biological support and creates a good environment for cell activation, communication between cells, and inducing cell organization.

Understanding COVID-19 vaccine hesitancy: A cross-sectional study in Malang District, Indonesia.

Introduction: Vaccine hesitancy could undermine efforts to reduce incidence of coronavirus disease 2019 (COVID-19). Understanding COVID-19 vaccine hesitancy is crucial to tailoring strategies to increase vaccination acceptance. This study aims to investigate the prevalence of and the reasons for COVID-19 vaccine hesitancy in Malang District, Indonesia.

Dataset of TPACK in teaching practice: Adversity quotient, attitude computer technology and self-efficacy among Indonesian teachers.

This dataset describes the measurement of adversity quotient (AQ), attitude computer technology (ACT), and self-efficacy with computer technology (SCT) of Indonesian teachers in implementing the technological pedagogical content knowledge (TPACK) concept in their teaching practice. The online survey was distributed to collect data on demographic information (4 items), AQ (11 items), ACT (19 items), SCT (22 items), and TPACK (5 items). It was carried out from August to September 2022.

Two new chromanone acids from the stem bark of Lauterb.

Three chromanone acids were isolated from the stem bark of Lauterb. Among them are two new chromanone acids, calopeekelioic acids A () and B (), along with calolongic acid (), Their structures were established by analyzing a combination of HRESIMS, 1 D, and 2 D NMR spectra. Chromanone acids were evaluated for their antiplasmodial activity against strain 3D7.

Assessment of the health risks related with metal accumulation in blue swimming crab (Portunus pelagicus) caught in East Java coastal waters, Indonesia.

Blue swimming crab (BSC) Portunus pelagicus from the Bali Strait had the lowest Cu, Zn, Cr, Pb, Cd and Hg concentrations compared to those from the Java Sea and the Madura Strait. The order of metal concentrations in BSC was Cu > Zn > Cr > Pb > Cd > Hg. The levels of six metals in BSC from all stations were less than the maximum allowable limits.

The application of honey in wound care of raw surface at spontaneous rupture submandibular abscess that extends to submental and right neck: A case report.

Introduction: Honey has been reported to accelerate wound healing. The use of honey in wound care mostly uses medicated (Manuka) honey. There are still few who report using Nusantara honey, local honey from Indonesia, as a wound dressing.

Date palm (Phoenix dactylifera) consumption as a nutrition source for mild anemia.

Objective: The purpose of this review is to describe an intervention that utilizes dates as a source of nutrition for pregnant women to increase hemoglobin levels in the blood in anemia incidence. The findings in this study are related to the use of dates to increase hemoglobin levels in the blood in pregnant women.

Methods: This study uses search databases used in PubMed, Science Direct, and Google Scholar.

Three novel quinolinone alkaloids from the leaves of .

Three previously unreported quinolinone alkaloids: melicodenines J-L (-) and six known compounds (-), were isolated from the leaves of (Seem) T.G. Hartley.

Social Media Addiction and Mental Health Among University Students During the COVID-19 Pandemic in Indonesia.

Deteriorating mental health among university students during the COVID-19 pandemic is a serious worldwide public health concern. This study aims to examine the linkage between social media addiction and mental health of university students in Indonesia and to address whether family relationship and religiosity may mitigate the harmful effects of social media on the mental health of students at this time. We collected data from 709 students at universities across the country between June 3 and June 20, 2020.

Is third molar development affected by third molar impaction or impaction-related parameters?

Objective: To evaluate the effect of third molar impaction and impaction-related parameters on third molar development.

Materials And Methods: Panoramic radiographs (N=3972) from 473 males and 558 females between 3.2 and 23.

Alkaloid and benzopyran compounds of Melicope latifolia fruit exhibit anti-hepatitis C virus activities.

Background: New agents for developing alternative or complementary medicine to treat the hepatitis C virus (HCV) are still needed due to high rates of HCV infection globally and the current limitations of available treatments. Treatment of HCV with a combination of direct acting antivirals have been shown to be approximately 90% effective but will be limited in the future due to the emergence of drug resistance and high cost. The leaves of Melicope latifolia have previously been reported to have anti-HCV activity and are a potential source of bioactive compounds for future novel drug development.

Two new 2-arylbenzofurans from L. and their cytotoxicity towards cancer cell.

Two new 2-arylbenzofurans, sesbagrandiflorain D () and E () along with two known 2-arylbenzofurans, spinosan A () and spinosan B () were isolated from the stem bark of L. The structure of two new compounds established by HRESIMS, 1 D NMR (H, C) and 2 D NMR (HMQC, HMBC) spectra. Compounds (-) assayed for their cytotoxicity towards three human cancer cells (MCF-7, HeLa, and WiDr).

Two new pyranoxanthones from the stem bark of P.F. Stevens.

Two new pyranoxanthones, calotetrapterins D () and E (), were isolated from the stem bark of P.F. Stevens along with α-mangostin ().

Vitamin D Ameliorates Kidney Ischemia Reperfusion Injury via Reduction of Inflammation and Myofibroblast Expansion.

The incidence rate of Acute Kidney Injury (AKI) gets escalated each year. Kidney ischemia/reperfusion injury (IR injury) is the main cause of AKI after major cardiovascular surgery, trauma, or kidney transplantation. Reperfusion is considered essential for ischemic tissue.

Two novel coumarins bearing an acetophenone derivative from the leaves of .

Meliquercifolins A (), and B (), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of along with three known compounds, melicodenines E (), F () and I (). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D and 2 D NMR). Cytotoxic activities of compounds ( towards three human cancer cells (HeLa, MCF-7, P-388), compounds , and showed very potent activity against Hela cells with IC values 2.

Calodioscurins A and B, two new isoprenylated xanthones from the stem bark of P.F. Stevens.

Two new isoprenylated xanthones, calodioscurin A () and B () were isolated from the stem bark of P.F. Stevens along with two known isoprenylated 4-phenylcoumarins, apetalolide () and methyl inophyllum P ().

Calotetrapterins A-C, three new pyranoxanthones and their cytotoxicity from the stem bark of Miq.

Three new pyranoxanthones, calotetrapterins A-C (-) were isolated from the stem bark of Miq along with three known xanthones, α-mangostin (), garciniafuran (), and pyranojacareubin (). All structures were elucidated based on their IR, UV, HRESIMS, 1 D (H, C) and 2 D (HMBC, HMQC) NMR spectral data. Compounds - were tested to P-388 cells for cytotoxic activity, compound 2 exhibited high activity with IC value 1.