Exploring the potential of pheophorbide A, a chlorophyll-derived compound in modulating GLUT for maintaining glucose homeostasis.

Introduction: Pheophorbide A, a chlorophyll-breakdown product, is primarily investigated for its anti-oxidant and anti-inflammatory activity. Recent reports on pheophorbide A have shown its potential in lowering blood glucose levels, thus leading to the exploration of its use in diabetes management. Literature has also shown its effect on enhanced insulin secretion, whereas its mechanism on glucose stimulated insulin secretion (GSIS) in pancreatic β cells remains unexplored.

Exploring antidiabetic potential of a polyherbal formulation Madhurakshak Activ: An in vitro and in silico study.

Madhurakshak Activ (MA), a commercial polyherbal antidiabetic preparation is known to manage diabetes mellitus (DM) by reducing blood glucose levels. However, lacks systematic mechanistic evaluation for their molecular and cellular mode of actions. In the present study, hydro-alcoholic and aqueous extract of MA were evaluated for their effects on glucose adsorption, diffusion, amylolysis kinetics and transport across the yeast cells using in vitro techniques.

Multimode Assessment of Commercial Polyherbal Formulation: an In Vitro and In Silico Approach.

Antidiabetic polyherbal formulations (APH) are used in management of diabetes mellitus (DM). High glucose levels in DM are related to oxidative stress leading to its associated complications. Therefore, assessing antioxidant activity of various APH might unveil an antioxidant-rich formulation for management of DM and its associated complications.

Comparative study of six antidiabetic polyherbal formulation for its multimodal approaches in diabetes management.

Commercial antidiabetic polyherbal formulations (APH) are available with claimed hypoglycemic activities; yet they lack systematic scientific studies leading to their limited global acceptance. In the present study, six selected APH from the Indian market were evaluated for their phytochemical contents, anti-hyperglycemic, anti-hyperlipidemic, antioxidant activities and further identifying the major antidiabetic bioactive compound of "MA" by HPLC-ESI-MS/MS. Our results revealed highest TPC (136.

Health risk assessment of Macro, Trace-elements and heavy metal in various Indian Antidiabetic Polyherbal formulations.

Diabetes mellitus, a global pandemic, can be holistically managed with the use of polyherbal formulations which is an accessible form of treatment in developing countries due to fewer side effects, economical and easily available. Commercial polyherbal formulation lacks systemic based scientific study, thus it is suspected to be associated with many contaminations and related toxicities, one of which is considered to be elemental health hazards. Therefore, the present study is designed to assess six selected antidiabetic polyherbal formulations from the Indian market for their element contents, quality, and health risk assessment.