About 8- and approximately 84-h rhythms in endotheliocytes as in endothelin-1 and effect of trauma.

Population densities (PD) of capillaries (C) and endotheliocytes (E) were determined in pinnal dermis of C57BL mice before and after trauma. Moving (and overall) least-squares spectra before trauma detected in EPD (versus CPD) pronounced 3.5-day (circasemiseptan) and 8-h oscillations corresponding to components of the endothelin-1 chronome in human blood plasma reported earlier.

[The internal variability of the mesothelium during regeneration following trauma applied at various times of the day].

A quantitative investigation of the mitotic activity (MA) dynamics, size of the cells, amount of their mutual contacts (as an index of the epithelial layer regulation) and amount of nucleoli in the nuclei of mesothelium after a trauma, performed at 9 a.m. and at 9 p.

[Space-time characteristics of DNA synthesis in mesothelial cells of the rat after surgery at different times of the day].

Differences in the DNA synthesis dynamics (according to the label index-LI) and those of mitotic activity (MA) in the mesothelium of the rat parietal peritoneum have been studied after burn performed at 9 AM, or at 9 PM. A number of peculiarities in the regeneration character are dependent on the day time of the operation. Immediately after the PM operation inhibition of both DNA synthesis and MA is manifected more distinctly and lasts longer, but then activation of the processes occurs more intensively the LI and MA values are greater than after the AM operation.

[Dynamics of the state of the granulation tissue after trauma inflicted at different times of day].

Dynamics on number of fibroblasts and amount of collagenous fibres in the granular tissue of the mouse ear skin was studied after trauma inflicted at 7 a. m., 15 or 23 p.

[Nucleoli of mesothelial cells during regeneration after injuries inflicted at different times of the day].

Quantitative changes in nucleoli of the mesothelial cells of the rabbit parietal peritoneum have been studied under regeneration when trauma is performed at 8--10 or at 20--22 o'clock. The animals are killed every 3 h after the operation, for 5 days. The nucleoli are studied continuously along 12.

[Endothelial cell nucleoli during regeneration after injuries inflicted at different times of the day].

Quantitative changes in the state of the nucleolar apparatus of endothelial cells in the rabbit jugular veins were studied at regeneration after trauma produced either at 8-10 a.m. or at 8-10 p.

[Effect of the time of the day when the lesion was produced on the course of mesothelial proliferation].

The course of mitotic activity in the rabbit mesothelium of parietal peritoneum was studied depending upon the daytime when the lesion was produced. In the first series of experiments (I) the operation was performed from 8 to 10 a. m.

[Analysis of the spatial organization of the endothelium of several major vessels].

The aim of the investigation was to appreciate quantitatively the degree of endothelial heteromorphy and its spatial organization according to some indices allowing morphofunctional interpretation of their importance. Endothelium of the rabbit protal and jugular veins was studied in the flat film preparations along the length of 16--20 mm continuously. To elucidate changeability in tissue state, autocorrelative function was calculated with the following determination of spectral density.

[Relationship between the time of day of trauma infliction and the dynamics of endothelial mitotic activity].

Endothelial mitotic activity of the rabbit jugular veins depending on the daytime of trauma infliction was studied. In the first series of experiments (I), the operations were performed from 8 to 10 a. m.

[Tissue organization of mesothelium under normal conditions and during reparative regeneration].

The investigation of tissue organization of the mesothelium by non-parametric statistic methods has shown that under conditions of reparative regeneration the principle of organization of the mesothelium as a tissue is preserved. Heteromorphism characteristic of the normal mesothelium is increased at all steps of regeneration, and the degree of the layer organization is decreased. The mitotic activity leading to the reparation of defect develops undulatorily, the periodicity of time does not coincide with the periodicity in space.

[Reactive growth of the mesothelium of the parietal leaf of the peritoneum].

In the process of reparative regeneration of the mesothelium caused by suturing of a portion of the jugular vein into the peritoneum defect the inflammatory mesothelial growings are formed. They have different configuration, consist only of the mesotheliumor the connective tissue covered with the mesothelium and are observed from the 4th day till 3 months after operation, being always faced to the abdominal cavity. The capacity of mesothelial cells to high mitotic activity and wedging out from the layer underlies the formation of posttraumatic structures of the mesothelium.