Comparing the Safety and Efficacy of Overstitch, X-Tack, and Endoscopic Hand Suturing for Closure of Gastrointestinal Defects After Endoscopic Resection: A systematic review and Meta-Analysis.

Background And Aims: Data comparing the efficacy and safety of Overstitch, X-Tack, and Endoscopic Hand Suturing (EHS) for closure of gastrointestinal defects after endoscopic resection is limited. We conducted a meta-analysis of the available data.

Methods: Online databases were searched for studies evaluating different closure systems for gastrointestinal defects.

Evaluation of knowledge and awareness of diabetes in higher secondary level students of Kaski district: A cross-sectional study.

Studies have shown that the knowledge of diabetes among adults in Nepal is poor. This study aimed to evaluate the knowledge regarding diabetes in secondary level (i.e.

Knowledge, Attitude, and Practice on Antibiotic Use and Resistance Among Undergraduates, Pokhara Metropolitan, Nepal.

Antimicrobial resistance (AMR) is a global health problem contributing to increasing rates of morbidity and mortality throughout the world. Inadequate knowledge and misconceptions surrounding antibiotics and their overuse can significantly contribute to the growth and spread of AMR. This study aimed to assess knowledge, attitudes, and practices (KAP) regarding antibiotic use and resistance among undergraduates in Pokhara, Nepal, and examine associations of knowledge and attitudes with demographic factors and specific antibiotic use practices.

Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational study.

Objective: This study analyzed the practice of switching intravenous antibiotics to oral dosage form in a tertiary care hospital of Nepal.

Design: A prospective observational study was performed among patients admitted to medical/surgical wards in a private tertiary care hospital of Nepal.

Methods: Hospitalized adult patients who received IV antibiotics for at least 48 hours and met the eligibility criteria were enrolled in the study.

Pharmaceutical waste management legislations: Where do ASEAN countries stand in harmonization? A review of regulatory documents.

Although healthcare waste management (HCWM) legislations prevail in Association of Southeast Asian Nations (ASEAN), there appears a prominent gap in standalone pharmaceutical waste management (PWM) legislation making harmonization of PWM challenging in the region. This review is aimed to comprehensively overview the PWM-related legislations in ASEAN, comprising of 10 economically rising countries in Southeast Asia. The relevant regulatory documents, that were promulgated till August 31, 2024 and that were in English or officially translated in English, were extracted from PubMed/Medline, Scopus, Science Direct, Google Scholar, and respective country's government websites.

Comprehensive screening and analysis of pharmaceuticals and pharmaceutically active chemicals in wastewater: health and environmental hazards and removal efficiency of wastewater treatment plant in Malaysia.

Wastewater treatment plant (WWTP) is a sustainable technique for making wastewater reusable for non-potable purposes. However, in developing countries, most conventional WWTPs are not equipped to trap all pharmaceutical residues (PRs) and pharmaceutically active chemicals (PhACs). This study aims to perform non-target screening of these contaminants in wastewater and explore health and environmental hazards and the removal efficiency of a WWTP in Malaysia.

Lanthanide binding peptide surfactants at air-aqueous interfaces for interfacial separation of rare earth elements.

Rare earth elements (REEs) are critical materials to modern technologies. They are obtained by selective separation from mining feedstocks consisting of mixtures of their trivalent cation. We are developing an all-aqueous, bioinspired, interfacial separation using peptides as amphiphilic molecular extractants.

Safety and efficacy of lumen-apposing metal stents for endoscopic ultrasound-guided drainage of pancreatic fluid collections: a systematic review and meta-analysis.

Endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFCs) has variable outcomes according to the type of lumen-apposing metal stent (LAMS) used. We aimed to perform a systematic review and meta-analysis of the available data.Online databases, including EMBASE, PubMed, and SCOPUS, were searched from inception to 30 January 2024.

Incidence of aphid-transmitted viruses in raspberry and raspberry aphids in Norway and experiments on aphid transmission of black raspberry necrosis virus.

Raspberry ( L.) is susceptible to aphid-borne viruses. We studied the incidence of four of them - black raspberry necrosis virus (BRNV), raspberry leaf mottle virus (RLMV), raspberry vein chlorosis virus (RVCV), and Rubus yellow net virus (RYNV) - in raspberry plants and aphids in and around Norwegian raspberry crops for three years (2019, 2021, and 2022).

Metaizeau technique in stabilizing Monteggia equivalent 1b associated proximal radial physeal injury in a rural setting: a case report.

Introduction: The Monteggia equivalent type 1b fracture, consisting of an ulnar shaft fracture and radial head dislocation, is a rare condition first described by Giovanni Battista Monteggia. The Metaizeau technique, emphasizing percutaneous intramedullary fixation to preserve bone healing and prevent growth plate damage, has gained prominence in managing these fractures.

Case Report: A 10-year-old boy presented with left forearm pain, swelling, and deformity following a fall while playing football.

Job Satisfaction among Medical Doctors in Nepal: A Descriptive Cross-sectional Study.

Introduction: Job satisfaction is an attitudinal variable representing the extent to which people like or dislike their jobs. It is a critical factor influencing healthcare quality, patient outcomes, and overall well-being in medical professionals. This study aimed to determine Job Satisfaction among medical doctors in Nepal.

X-ray Induced Cycling of Rare-Earth Elements between Bulk and Interfacial Liquid.

Reversible cycling of rare-earth elements between an aqueous electrolyte solution and its free surface is achieved by X-ray exposure. This exposure alters the competitive equilibrium between lanthanide ions bound to a chelating ligand, diethylenetriamine pentaacetic acid (DTPA), in the bulk solution and to insoluble monolayers of extractant di-hexadecyl phosphoric acid (DHDP) at its surface. Evidence for the exposure-induced temporal variations in the lanthanide surface density is provided by X-ray fluorescence near total reflection measurements.

Assessing the Indicators of Good Pharmacy Practice in Community Pharmacies: A Cross-Sectional Study.

To evaluate the extent to which pharmacies in Hetauda Sub-metropolitan City, Nepal adhere to the recommended practices outlined in the good pharmacy practice guidelines formulated by International Pharmaceutical Federation and draft developed by Nepal Pharmacy Council. Good Pharmacy Practice evaluates the safety, effectiveness, availability, and accessibility of medicines, ensuring their correct usage which is essential component of community pharmacies. Data was collected by visiting community pharmacies throughout Hetauda sub-metropolitan city.

Molecular Characterization of a Novel Rubodvirus Infecting Raspberries.

A novel negative-sense single-stranded RNA virus showing genetic similarity to viruses of the genus has been found in raspberry plants in the Czech Republic and has tentatively been named raspberry rubodvirus 1 (RaRV1). Phylogenetic analysis confirmed its clustering within the group, albeit distantly related to other members. A screening of 679 plant and 168 arthropod samples from the Czech Republic and Norway revealed RaRV1 in 10 raspberry shrubs, one batch of , and one individual of .

Indirect comparison of various lumen-apposing metal stents for EUS-guided biliary and gallbladder drainage: a systematic review and meta-analysis.

Background And Aims: Studies assessing EUS-guided biliary drainage (EUS-BD) or gallbladder drainage (EUS-GB) using lumen-apposing metal stents (LAMSs) have shown variable results based on the type of LAMS. We performed a meta-analysis of the available data.

Methods: Multiple online databases were searched for studies using LAMSs (Axios [Boston Scientific, Marlborough, Mass, USA] or Spaxus [Taewoong Medical Co, Gimpo, Korea]) for EUS-BD and EUS-GB.

Health-related quality of life among people with diabetes: A cross-sectional study in Hail region, Saudi Arabia ​.

Background: Diabetes Mellitus is a serious and expanding health problem, together with the issues of health- related quality of life (HRQoL). This further puts pressure on the government to allocate more funds for public healthcare.

Objectives: This study was devised to evaluate the health-related quality of life of people living with diabetes in Hail region of Saudi Arabia.

Effects of developmental exposure to individual and combined PFAS on development and behavioral stress responses in larval zebrafish.

Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic chemicals known for their widespread use and persistence in the environment. Laboratory and epidemiological studies investigating these compounds have signaled their neurotoxic and endocrine-disrupting propensities, prompting further research into their effects on behavioral stress responses and their potential role as risk factors for stress-related disorders such as anxiety and depression. This study elucidates the ramifications of early developmental exposures to individual and combined PFAS on the development and behavioral stress responses of larval zebrafish (Danio rerio), an established model in toxicological research.

Clinical and psychological impact of lip repositioning surgery in the management of excessive gingival display.

Background: Excessive gingival display (EGD), also known as a gummy smile, is characterized by overexposure of the maxillary gingiva on smiling. EGD can cause embarrassment and reduce patient satisfaction. This study aimed to evaluate the clinical and psychological effects of lip repositioning surgery on the management of EGD.