Publications by authors named "Sapir Muvkadi"
The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones performing distinct functions. The liver is also subject to extensive temporal regulation, orchestrated by the interplay of the circadian clock, systemic signals and feeding rhythms.
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- The study investigates how hypoxic events (like those from asthma, COPD, and OSA) interact with the body's circadian rhythms, revealing that tissue responses to hypoxia vary based on the time of day.
- Researchers found that the circadian clock influences how tissues react to hypoxia at both transcriptional and posttranscriptional levels, leading to mismatched circadian rhythms between different tissues.
- This misalignment is worsened by intermittent hypoxia, common in OSA, suggesting that disrupted circadian rhythms might play a role in the development of OSA and similar hypoxia-related conditions.